diff --git a/CHANGELOG.md b/CHANGELOG.md
index 05885d8d..0664bab4 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -7,6 +7,7 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 ## Unreleased
 
 ### Added
+- Support custom packer and unpacker factories (#191).
 
 ### Changed
 
diff --git a/tarantool/connection.py b/tarantool/connection.py
index 5849994c..fcaa7e83 100644
--- a/tarantool/connection.py
+++ b/tarantool/connection.py
@@ -21,8 +21,12 @@
 
 import msgpack
 
-from tarantool.response import Response
+from tarantool.response import (
+    unpacker_factory as default_unpacker_factory,
+    Response,
+)
 from tarantool.request import (
+    packer_factory as default_packer_factory,
     Request,
     # RequestOK,
     RequestCall,
@@ -357,7 +361,9 @@ def __init__(self, host, port,
                  ssl_key_file=DEFAULT_SSL_KEY_FILE,
                  ssl_cert_file=DEFAULT_SSL_CERT_FILE,
                  ssl_ca_file=DEFAULT_SSL_CA_FILE,
-                 ssl_ciphers=DEFAULT_SSL_CIPHERS):
+                 ssl_ciphers=DEFAULT_SSL_CIPHERS,
+                 packer_factory=default_packer_factory,
+                 unpacker_factory=default_unpacker_factory):
         """
         :param host: Server hostname or IP address. Use ``None`` for
             Unix sockets.
@@ -395,6 +401,16 @@ def __init__(self, host, port,
         :param encoding: ``'utf-8'`` or ``None``. Use ``None`` to work
             with non-UTF8 strings.
 
+            If non-default
+            :paramref:`~tarantool.Connection.packer_factory` option is
+            used, :paramref:`~tarantool.Connection.encoding` option
+            value is ignored on encode until the factory explicitly uses
+            its value. If non-default
+            :paramref:`~tarantool.Connection.unpacker_factory` option is
+            used, :paramref:`~tarantool.Connection.encoding` option
+            value is ignored on decode until the factory explicitly uses
+            its value.
+
             If ``'utf-8'``, pack Unicode string (:obj:`str`) to
             MessagePack string (`mp_str`_) and unpack MessagePack string
             (`mp_str`_) Unicode string (:obj:`str`), pack :obj:`bytes`
@@ -429,6 +445,13 @@ def __init__(self, host, port,
         :param use_list:
             If ``True``, unpack MessagePack array (`mp_array`_) to
             :obj:`list`. Otherwise, unpack to :obj:`tuple`.
+
+            If non-default
+            :paramref:`~tarantool.Connection.unpacker_factory` option is
+            used,
+            :paramref:`~tarantool.Connection.use_list` option value is
+            ignored on decode until the factory explicitly uses its
+            value.
         :type use_list: :obj:`bool`, optional
 
         :param call_16:
@@ -463,6 +486,23 @@ def __init__(self, host, port,
             suites the connection can use.
         :type ssl_ciphers: :obj:`str` or :obj:`None`, optional
 
+        :param packer_factory: Request MessagePack packer factory.
+            Supersedes :paramref:`~tarantool.Connection.encoding`. See
+            :func:`~tarantool.request.packer_factory` for example of
+            a packer factory.
+        :type packer_factory:
+            callable[[:obj:`~tarantool.Connection`], :obj:`~msgpack.Packer`],
+            optional
+
+        :param unpacker_factory: Response MessagePack unpacker factory.
+            Supersedes :paramref:`~tarantool.Connection.encoding` and
+            :paramref:`~tarantool.Connection.use_list`. See
+            :func:`~tarantool.response.unpacker_factory` for example of
+            an unpacker factory.
+        :type unpacker_factory:
+            callable[[:obj:`~tarantool.Connection`], :obj:`~msgpack.Unpacker`],
+            optional
+
         :raise: :exc:`~tarantool.error.ConfigurationError`,
             :meth:`~tarantool.Connection.connect` exceptions
 
@@ -514,6 +554,8 @@ def __init__(self, host, port,
             IPROTO_FEATURE_ERROR_EXTENSION: False,
             IPROTO_FEATURE_WATCHERS: False,
         }
+        self._packer_factory_impl = packer_factory
+        self._unpacker_factory_impl = unpacker_factory
 
         if connect_now:
             self.connect()
@@ -1749,3 +1791,9 @@ def _check_features(self):
         features_list = [val for val in CONNECTOR_FEATURES if val in server_features]
         for val in features_list:
             self._features[val] = True
+
+    def _packer_factory(self):
+        return self._packer_factory_impl(self)
+
+    def _unpacker_factory(self):
+        return self._unpacker_factory_impl(self)
diff --git a/tarantool/request.py b/tarantool/request.py
index 7274b8d2..e9ea6e01 100644
--- a/tarantool/request.py
+++ b/tarantool/request.py
@@ -63,7 +63,7 @@
 
 from tarantool.msgpack_ext.packer import default as packer_default
 
-def build_packer(conn):
+def packer_factory(conn):
     """
     Build packer to pack request.
 
@@ -148,7 +148,7 @@ def __init__(self, conn):
         self._body = ''
         self.response_class = Response
 
-        self.packer = build_packer(conn)
+        self.packer = conn._packer_factory()
 
     def _dumps(self, src):
         """
diff --git a/tarantool/response.py b/tarantool/response.py
index 7fef6e90..3ef931df 100644
--- a/tarantool/response.py
+++ b/tarantool/response.py
@@ -32,7 +32,7 @@
 
 from tarantool.msgpack_ext.unpacker import ext_hook as unpacker_ext_hook
 
-def build_unpacker(conn):
+def unpacker_factory(conn):
     """
     Build unpacker to unpack request response.
 
@@ -108,7 +108,7 @@ def __init__(self, conn, response):
         # created in the __new__().
         # super(Response, self).__init__()
 
-        unpacker = build_unpacker(conn)
+        unpacker = conn._unpacker_factory()
 
         unpacker.feed(response)
         header = unpacker.unpack()
diff --git a/test/suites/__init__.py b/test/suites/__init__.py
index ee951038..49014e97 100644
--- a/test/suites/__init__.py
+++ b/test/suites/__init__.py
@@ -22,6 +22,7 @@
 from .test_package import TestSuite_Package
 from .test_error_ext import TestSuite_ErrorExt
 from .test_push import TestSuite_Push
+from .test_connection import TestSuite_Connection
 
 test_cases = (TestSuite_Schema_UnicodeConnection,
               TestSuite_Schema_BinaryConnection,
@@ -29,7 +30,8 @@
               TestSuite_Mesh, TestSuite_Execute, TestSuite_DBAPI,
               TestSuite_Encoding, TestSuite_Pool, TestSuite_Ssl,
               TestSuite_Decimal, TestSuite_UUID, TestSuite_Datetime,
-              TestSuite_Interval, TestSuite_ErrorExt, TestSuite_Push,)
+              TestSuite_Interval, TestSuite_ErrorExt, TestSuite_Push,
+              TestSuite_Connection,)
 
 def load_tests(loader, tests, pattern):
     suite = unittest.TestSuite()
diff --git a/test/suites/test_connection.py b/test/suites/test_connection.py
new file mode 100644
index 00000000..4132d35e
--- /dev/null
+++ b/test/suites/test_connection.py
@@ -0,0 +1,161 @@
+import sys
+import unittest
+
+import decimal
+import msgpack
+
+import tarantool
+import tarantool.msgpack_ext.decimal as ext_decimal
+
+from .lib.skip import skip_or_run_decimal_test, skip_or_run_varbinary_test
+from .lib.tarantool_server import TarantoolServer
+
+class TestSuite_Connection(unittest.TestCase):
+    @classmethod
+    def setUpClass(self):
+        print(' CONNECTION '.center(70, '='), file=sys.stderr)
+        print('-' * 70, file=sys.stderr)
+        self.srv = TarantoolServer()
+        self.srv.script = 'test/suites/box.lua'
+        self.srv.start()
+
+        self.adm = self.srv.admin
+        self.adm(r"""
+            box.schema.user.create('test', {password = 'test', if_not_exists = true})
+            box.schema.user.grant('test', 'read,write,execute', 'universe')
+
+            box.schema.create_space('space_varbin')
+
+            box.space['space_varbin']:format({
+                {
+                    'id',
+                    type = 'number',
+                    is_nullable = false
+                },
+                {
+                    'varbin',
+                    type = 'varbinary',
+                    is_nullable = false,
+                }
+            })
+
+            box.space['space_varbin']:create_index('id', {
+                type = 'tree',
+                parts = {1, 'number'},
+                unique = true})
+
+            box.space['space_varbin']:create_index('varbin', {
+                type = 'tree',
+                parts = {2, 'varbinary'},
+                unique = true})
+        """)
+
+    def setUp(self):
+        # prevent a remote tarantool from clean our session
+        if self.srv.is_started():
+            self.srv.touch_lock()
+
+    @skip_or_run_decimal_test
+    def test_custom_packer(self):
+        def my_ext_type_encoder(obj):
+            if isinstance(obj, decimal.Decimal):
+                obj = obj + 1
+                return msgpack.ExtType(ext_decimal.EXT_ID, ext_decimal.encode(obj, None))
+            raise TypeError("Unknown type: %r" % (obj,))
+
+        def my_packer_factory(_):
+            return msgpack.Packer(default=my_ext_type_encoder)
+
+        self.con = tarantool.Connection(self.srv.host, self.srv.args['primary'],
+                                        user='test', password='test',
+                                        packer_factory=my_packer_factory)
+
+        resp = self.con.eval("return ...", (decimal.Decimal('27756'),))
+        self.assertSequenceEqual(resp, [decimal.Decimal('27757')])
+
+    def test_custom_packer_supersedes_encoding(self):
+        def my_packer_factory(_):
+            return msgpack.Packer(use_bin_type=False)
+
+        self.con = tarantool.Connection(self.srv.host, self.srv.args['primary'],
+                                        user='test', password='test',
+                                        encoding='utf-8',
+                                        packer_factory=my_packer_factory)
+
+        # bytes -> mp_str (string) for encoding=None
+        # bytes -> mp_bin (varbinary) for encoding='utf-8'
+        resp = self.con.eval("return type(...)", (bytes(bytearray.fromhex('DEADBEAF0103')),))
+        self.assertSequenceEqual(resp, ['string'])
+
+    @skip_or_run_decimal_test
+    def test_custom_unpacker(self):
+        def my_ext_type_decoder(code, data):
+            if code == ext_decimal.EXT_ID:
+                return ext_decimal.decode(data, None) - 1
+            raise NotImplementedError("Unknown msgpack extension type code %d" % (code,))
+
+        def my_unpacker_factory(_):
+            if msgpack.version >= (1, 0, 0):
+                return msgpack.Unpacker(ext_hook=my_ext_type_decoder, strict_map_key=False)
+            return msgpack.Unpacker(ext_hook=my_ext_type_decoder)
+
+
+        self.con = tarantool.Connection(self.srv.host, self.srv.args['primary'],
+                                        user='test', password='test',
+                                        unpacker_factory=my_unpacker_factory)
+
+        resp = self.con.eval("return require('decimal').new('27756')")
+        self.assertSequenceEqual(resp, [decimal.Decimal('27755')])
+
+    @skip_or_run_varbinary_test
+    def test_custom_unpacker_supersedes_encoding(self):
+        def my_unpacker_factory(_):
+            if msgpack.version >= (0, 5, 2):
+                if msgpack.version >= (1, 0, 0):
+                    return msgpack.Unpacker(raw=True, strict_map_key=False)
+
+                return msgpack.Unpacker(raw=True)
+            return msgpack.Unpacker(encoding=None)
+
+        self.con = tarantool.Connection(self.srv.host, self.srv.args['primary'],
+                                        user='test', password='test',
+                                        encoding='utf-8',
+                                        unpacker_factory=my_unpacker_factory)
+
+        data_id = 1
+        data_hex = 'DEADBEAF'
+        data = bytes(bytearray.fromhex(data_hex))
+        space = 'space_varbin'
+
+        self.con.execute("""
+            INSERT INTO "%s" VALUES (%d, x'%s');
+        """ % (space, data_id, data_hex))
+
+        resp = self.con.execute("""
+            SELECT * FROM "%s" WHERE "varbin" == x'%s';
+        """ % (space, data_hex))
+        self.assertSequenceEqual(resp, [[data_id, data]])
+
+    def test_custom_unpacker_supersedes_use_list(self):
+        def my_unpacker_factory(_):
+            if msgpack.version >= (1, 0, 0):
+                return msgpack.Unpacker(use_list=False, strict_map_key=False)
+            return msgpack.Unpacker(use_list=False)
+
+        self.con = tarantool.Connection(self.srv.host, self.srv.args['primary'],
+                                        user='test', password='test',
+                                        use_list=True,
+                                        unpacker_factory=my_unpacker_factory)
+
+        resp = self.con.eval("return {1, 2, 3}")
+        self.assertIsInstance(resp[0], tuple)
+
+    @classmethod
+    def tearDown(self):
+        if hasattr(self, 'con'):
+            self.con.close()
+
+    @classmethod
+    def tearDownClass(self):
+        self.srv.stop()
+        self.srv.clean()
diff --git a/test/suites/test_error_ext.py b/test/suites/test_error_ext.py
index 199e7b50..89f5c35f 100644
--- a/test/suites/test_error_ext.py
+++ b/test/suites/test_error_ext.py
@@ -8,8 +8,6 @@
 
 from tarantool.msgpack_ext.packer import default as packer_default
 from tarantool.msgpack_ext.unpacker import ext_hook as unpacker_ext_hook
-from tarantool.request import build_packer
-from tarantool.response import build_unpacker
 
 from .lib.tarantool_server import TarantoolServer
 from .lib.skip import skip_or_run_error_ext_type_test
@@ -273,7 +271,7 @@ def test_msgpack_decode(self):
                     unpacker_ext_hook(
                         3,
                         case['msgpack'],
-                        build_unpacker(conn)
+                        conn._unpacker_factory(),
                     ),
                     case['python'])
 
@@ -330,7 +328,7 @@ def test_msgpack_encode(self):
                 case = self.cases[name]
                 conn = getattr(self, case['conn'])
 
-                self.assertEqual(packer_default(case['python'], build_packer(conn)),
+                self.assertEqual(packer_default(case['python'], conn._packer_factory()),
                                  msgpack.ExtType(code=3, data=case['msgpack']))
 
     @skip_or_run_error_ext_type_test
diff --git a/test/suites/test_interval.py b/test/suites/test_interval.py
index a3458ad7..2252ebe8 100644
--- a/test/suites/test_interval.py
+++ b/test/suites/test_interval.py
@@ -9,7 +9,6 @@
 
 from tarantool.msgpack_ext.packer import default as packer_default
 from tarantool.msgpack_ext.unpacker import ext_hook as unpacker_ext_hook
-from tarantool.response import build_unpacker
 
 from .lib.tarantool_server import TarantoolServer
 from .lib.skip import skip_or_run_datetime_test
@@ -154,7 +153,7 @@ def test_msgpack_decode(self):
                 self.assertEqual(unpacker_ext_hook(
                                     6,
                                     case['msgpack'],
-                                    build_unpacker(self.con),
+                                    self.con._unpacker_factory(),
                                  ),
                                  case['python'])
 
@@ -206,13 +205,13 @@ def test_unknown_field_decode(self):
         case = b'\x01\x09\xce\x00\x98\x96\x80'
         self.assertRaisesRegex(
             MsgpackError, 'Unknown interval field id 9',
-            lambda: unpacker_ext_hook(6, case, build_unpacker(self.con)))
+            lambda: unpacker_ext_hook(6, case, self.con._unpacker_factory()))
 
     def test_unknown_adjust_decode(self):
         case = b'\x02\x07\xce\x00\x98\x96\x80\x08\x03'
         self.assertRaisesRegex(
             MsgpackError, '3 is not a valid Adjust',
-            lambda: unpacker_ext_hook(6, case, build_unpacker(self.con)))
+            lambda: unpacker_ext_hook(6, case, self.con._unpacker_factory()))
 
 
     arithmetic_cases = {