diff --git a/compiler/src/dotty/tools/dotc/core/Definitions.scala b/compiler/src/dotty/tools/dotc/core/Definitions.scala
index f10c7ae75ee7..ef5d0d1f7022 100644
--- a/compiler/src/dotty/tools/dotc/core/Definitions.scala
+++ b/compiler/src/dotty/tools/dotc/core/Definitions.scala
@@ -660,6 +660,9 @@ class Definitions {
     lazy val QuotedType_applyR = QuotedTypeModule.requiredMethodRef(nme.apply)
     def QuotedType_apply(implicit ctx: Context) = QuotedType_applyR.symbol
 
+  lazy val QuotedLiftableType = ctx.requiredClassRef("scala.quoted.Liftable")
+  def QuotedLiftableClass(implicit ctx: Context) = QuotedLiftableType.symbol.asClass
+
   def Unpickler_unpickleExpr = ctx.requiredMethod("scala.runtime.quoted.Unpickler.unpickleExpr")
   def Unpickler_liftedExpr = ctx.requiredMethod("scala.runtime.quoted.Unpickler.liftedExpr")
   def Unpickler_unpickleType = ctx.requiredMethod("scala.runtime.quoted.Unpickler.unpickleType")
diff --git a/compiler/src/dotty/tools/dotc/transform/ReifyQuotes.scala b/compiler/src/dotty/tools/dotc/transform/ReifyQuotes.scala
index ae9d63c3c222..3751c1a4d4a7 100644
--- a/compiler/src/dotty/tools/dotc/transform/ReifyQuotes.scala
+++ b/compiler/src/dotty/tools/dotc/transform/ReifyQuotes.scala
@@ -73,7 +73,7 @@ import dotty.tools.dotc.core.quoted._
  *      ...
  *      val y1$1 = args(1).asInstanceOf[Expr[Y]]
  *      ...
- *      { ... T1$1.unary_~ ... x ... '(y1$1.unary_~) ... }
+ *      { ... x1$1 .... '{ ... T1$1.unary_~ ... x1$1.toExpr.unary_~ ... y1$1.unary_~ ... } ... }
  *    }
  *    ```
  *  Note: the parameters of `foo` are kept for simple overloading resolution but they are not used in the body of `foo`.
@@ -375,9 +375,15 @@ class ReifyQuotes extends MacroTransformWithImplicits with InfoTransformer {
       }
       else body match {
         case body: RefTree if isCaptured(body, level + 1) =>
-          // Optimization: avoid the full conversion when capturing `x`
-          // in '{ x } to '{ x$1.unary_~ } and go directly to `x$1`
-          capturers(body.symbol)(body)
+          if (body.symbol.is(Inline)) {
+            // Optimization: avoid the full conversion when capturing inlined `x`
+            // in '{ x } to '{ x$1.toExpr.unary_~ } and go directly to `x$1.toExpr`
+            liftValue(capturers(body.symbol)(body))
+          } else {
+            // Optimization: avoid the full conversion when capturing `x`
+            // in '{ x } to '{ x$1.unary_~ } and go directly to `x$1`
+            capturers(body.symbol)(body)
+          }
         case _=>
           val (body1, splices) = nested(isQuote = true).split(body)
           pickledQuote(body1, splices, isType).withPos(quote.pos)
@@ -546,8 +552,11 @@ class ReifyQuotes extends MacroTransformWithImplicits with InfoTransformer {
             splice(tree)
           case tree: RefTree if isCaptured(tree, level) =>
             val capturer = capturers(tree.symbol)
-            if (tree.symbol.is(Inline)) capturer(tree)
-            else splice(capturer(tree).select(if (tree.isTerm) nme.UNARY_~ else tpnme.UNARY_~))
+            def captureAndSplice(t: Tree) =
+              splice(t.select(if (tree.isTerm) nme.UNARY_~ else tpnme.UNARY_~))
+            if (tree.symbol.is(Inline) && level == 0) capturer(tree)
+            else if (tree.symbol.is(Inline)) captureAndSplice(liftValue(capturer(tree)))
+            else captureAndSplice(capturer(tree))
           case Block(stats, _) =>
             val last = enteredSyms
             stats.foreach(markDef)
@@ -601,6 +610,21 @@ class ReifyQuotes extends MacroTransformWithImplicits with InfoTransformer {
         }
       }
 
+    private def liftValue(tree: Tree)(implicit ctx: Context): Tree = {
+      val reqType = defn.QuotedLiftableType.appliedTo(tree.tpe.widen)
+      val liftable = ctx.typer.inferImplicitArg(reqType, tree.pos)
+      liftable.tpe match {
+        case fail: SearchFailureType =>
+          ctx.error(i"""
+                  |
+                  | The access would be accepted with the right Liftable, but
+                  | ${ctx.typer.missingArgMsg(liftable, reqType, "")}""")
+          EmptyTree
+        case _ =>
+          liftable.select("toExpr".toTermName).appliedTo(tree)
+      }
+    }
+
     private def liftList(list: List[Tree], tpe: Type)(implicit ctx: Context): Tree = {
       list.foldRight[Tree](ref(defn.NilModule)) { (x, acc) =>
         acc.select("::".toTermName).appliedToType(tpe).appliedTo(x)
diff --git a/tests/run/i4455.check b/tests/run/i4455.check
new file mode 100644
index 000000000000..b22040ee9c71
--- /dev/null
+++ b/tests/run/i4455.check
@@ -0,0 +1,4 @@
+1
+3
+3
+5
diff --git a/tests/run/i4455/Macro_1.scala b/tests/run/i4455/Macro_1.scala
new file mode 100644
index 000000000000..9ac3070ed986
--- /dev/null
+++ b/tests/run/i4455/Macro_1.scala
@@ -0,0 +1,8 @@
+import scala.quoted._
+object Macros {
+  inline def foo(inline i: Int): Int = ~bar('(i))
+
+  inline def foo2(inline i: Int): Int = ~bar('(i + 1))
+
+  def bar(x: Expr[Int]): Expr[Int] = x
+}
diff --git a/tests/run/i4455/Test_2.scala b/tests/run/i4455/Test_2.scala
new file mode 100644
index 000000000000..18fc75a361c6
--- /dev/null
+++ b/tests/run/i4455/Test_2.scala
@@ -0,0 +1,9 @@
+import Macros._
+object Test {
+  def main(args: Array[String]): Unit = {
+    println(foo(1))
+    println(foo(3))
+    println(foo2(2))
+    println(foo2(4))
+  }
+}