diff --git a/compiler/src/dotty/tools/dotc/interpreter/Interpreter.scala b/compiler/src/dotty/tools/dotc/interpreter/Interpreter.scala
index 5be936d71ee1..bad6e4aca72c 100644
--- a/compiler/src/dotty/tools/dotc/interpreter/Interpreter.scala
+++ b/compiler/src/dotty/tools/dotc/interpreter/Interpreter.scala
@@ -83,12 +83,12 @@ class Interpreter(implicit ctx: Context) {
         val paramClasses = paramsSig(fn.symbol)
         val interpretedArgs = args.map(arg => interpretTreeImpl(arg, env))
         val constructor = getConstructor(clazz, paramClasses)
-        interpreted(constructor.newInstance(interpretedArgs: _*))
+        stopIfRuntimeException(constructor.newInstance(interpretedArgs: _*))
 
       case _: RefTree if tree.symbol.isStatic =>
         val clazz = loadClass(tree.symbol.owner.companionModule.fullName)
         val method = getMethod(clazz, tree.symbol.name, Nil)
-        interpreted(method.invoke(null))
+        stopIfRuntimeException(method.invoke(null))
 
       case tree: Apply =>
         val evaluatedPrefix = if (tree.symbol.isStatic) null else interpretPrefix(tree, env)
@@ -98,7 +98,7 @@ class Interpreter(implicit ctx: Context) {
         val paramClasses = paramsSig(tree.symbol)
         val interpretedArgs = interpretArgs(tree, env)
         val method = getMethod(clazz, tree.symbol.name, paramClasses)
-        interpreted(method.invoke(evaluatedPrefix, interpretedArgs: _*))
+        stopIfRuntimeException(method.invoke(evaluatedPrefix, interpretedArgs: _*))
 
       case tree: Ident if env.contains(tree.symbol) =>
         env(tree.symbol)
@@ -117,11 +117,15 @@ class Interpreter(implicit ctx: Context) {
       case Typed(expr, _) =>
         interpretTreeImpl(expr, env)
 
-      // Getting the underlying value of a value class. The value class is evaluated as its boxed representation
-      // as values in the interpreter are `Object`s. Therefore we just get it from the enviroment as is.
-      case Select(qualifier, _)
+      case Select(qualifier, name)
           if tree.symbol.owner.isValueClass && tree.symbol.is(ParamAccessor) && env.contains(qualifier.symbol) =>
-        env(qualifier.symbol)
+        val value = env(qualifier.symbol)
+        val clazz = value.getClass
+        if (clazz.getCanonicalName != tree.symbol.owner.showFullName) value // Already unboxed
+        else {
+          val method = getMethod(clazz, name, Nil)
+          stopIfRuntimeException(method.invoke(value))
+        }
 
       case SeqLiteral(elems, _) =>
         elems.map(elem => interpretTreeImpl(elem, env))
@@ -189,7 +193,7 @@ class Interpreter(implicit ctx: Context) {
     }
   }
 
-  private def interpreted[T](thunk: => T)(implicit pos: Position): T = {
+  private def stopIfRuntimeException[T](thunk: => T)(implicit pos: Position): T = {
     try thunk
     catch {
       case ex: RuntimeException =>
diff --git a/tests/pos/i3916/Macro_1.scala b/tests/pos/i3916/Macro_1.scala
new file mode 100644
index 000000000000..a981f575764a
--- /dev/null
+++ b/tests/pos/i3916/Macro_1.scala
@@ -0,0 +1,21 @@
+import scala.quoted._
+
+class FInterpolatorHelper(val sc: StringContext) extends AnyVal {
+  inline def ff(arg1: Any): String = ~FInterpolation.fInterpolation(sc, Seq('(arg1)))
+  inline def ff(arg1: Any, arg2: Any): String = ~FInterpolation.fInterpolation(sc, Seq('(arg1), '(arg2)))
+  inline def ff(arg1: Any, arg2: Any, arg3: Any): String = ~FInterpolation.fInterpolation(sc, Seq('(arg1), '(arg2), '(arg3)))
+  // ...
+}
+
+object FInterpolation {
+  private def liftSeq(args: Seq[Expr[Any]]): Expr[Seq[Any]] = args match {
+    case x :: xs  => '{ (~x) +: ~(liftSeq(xs))  }
+    case Nil => '(Seq(): Seq[Any])
+  }
+
+  def fInterpolation(sc: StringContext, args: Seq[Expr[Any]]): Expr[String] = {
+    val str: Expr[String] = sc.parts.mkString("")
+    val args1: Expr[Seq[Any]] = liftSeq(args)
+    '{  (~str).format(~args1: _*) }
+  }
+}
diff --git a/tests/pos/i3916/Test_2.scala b/tests/pos/i3916/Test_2.scala
new file mode 100644
index 000000000000..6da6c6997794
--- /dev/null
+++ b/tests/pos/i3916/Test_2.scala
@@ -0,0 +1,5 @@
+ object Test {
+  def main(args: Array[String]): Unit = {
+    println(new FInterpolatorHelper(StringContext("hello%s")).ff(5))
+  }
+}