diff --git a/.devcontainer/postCreate.sh b/.devcontainer/postCreate.sh
index c7965afff0..c75247bf18 100755
--- a/.devcontainer/postCreate.sh
+++ b/.devcontainer/postCreate.sh
@@ -2,7 +2,7 @@
 
 # Install dev dependencies from OPAM
 opam init -y --bare --disable-sandboxing
-opam switch create 5.2.0 --packages ocaml-option-static
+opam switch create 5.2.1 --packages ocaml-option-static
 opam install . --deps-only -y
 
 # For IDE support, install the OCaml language server
diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index d52e13f72a..8a7ccdb816 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -87,23 +87,23 @@ jobs:
       matrix:
         include:
           - os: ubuntu-latest # x64
-            ocaml_compiler: ocaml-variants.5.2.0+options,ocaml-option-static
+            ocaml_compiler: ocaml-variants.5.2.1+options,ocaml-option-static
             upload_binaries: true
             upload_libs: true
             # Build the playground compiler and run the benchmarks on the fastest runner
             build_playground: true
             benchmarks: true
           - os: buildjet-2vcpu-ubuntu-2204-arm # ARM
-            ocaml_compiler: ocaml-variants.5.2.0+options,ocaml-option-static
+            ocaml_compiler: ocaml-variants.5.2.1+options,ocaml-option-static
             upload_binaries: true
           - os: macos-13 # x64
-            ocaml_compiler: 5.2.0
+            ocaml_compiler: 5.2.1
             upload_binaries: true
           - os: macos-14 # ARM
-            ocaml_compiler: 5.2.0
+            ocaml_compiler: 5.2.1
             upload_binaries: true
           - os: windows-latest
-            ocaml_compiler: 5.2.0
+            ocaml_compiler: 5.2.1
             upload_binaries: true
 
           # Verify that the compiler still builds with older OCaml versions
diff --git a/CHANGELOG.md b/CHANGELOG.md
index cf206f1101..f893536f57 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -27,6 +27,7 @@
 - AST cleanup: Represent the arity of uncurried function definitions directly in the AST. https://github.com/rescript-lang/rescript/pull/7197
 - AST cleanup: Remove Pexp_function from the AST. https://github.com/rescript-lang/rescript/pull/7198
 - Remove unused code from Location and Rescript_cpp modules. https://github.com/rescript-lang/rescript/pull/7150
+- Build with OCaml 5.2.1. https://github.com/rescript-lang/rescript-compiler/pull/7201
 
 # 12.0.0-alpha.5
 
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index 99e00963fd..f4b114ffc7 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -47,7 +47,7 @@ Make sure you have [opam](https://opam.ocaml.org/doc/Install.html) installed on
 opam init
 
 # Any recent OCaml version works as a development compiler
-opam switch create 5.2.0 # can also create local switch with opam switch create
+opam switch create 5.2.1 # can also create local switch with opam switch create
 
 # Install dev dependencies from OPAM
 opam install . --deps-only --with-test --with-dev-setup -y