diff --git a/.github/workflows/mypy.yml b/.github/workflows/mypy.yml
new file mode 100644
index 0000000000..181821d6f5
--- /dev/null
+++ b/.github/workflows/mypy.yml
@@ -0,0 +1,44 @@
+name: mypy
+
+on:
+  pull_request:
+  push:
+    branches: [main]
+
+jobs:
+  mypy:
+    runs-on: ubuntu-latest
+    defaults:
+      run:
+        shell: bash -l {0}
+    steps:
+      - uses: actions/checkout@v4
+      - name: Cache conda
+        uses: actions/cache@v4
+        env:
+          # Increase this value to reset cache if environment.yml has not changed
+          CACHE_NUMBER: 0
+        with:
+          path: ~/conda_pkgs_dir
+          key: ${{ runner.os }}-py310-conda-${{ env.CACHE_NUMBER }}-${{
+            hashFiles('environment.yml') }}
+      - uses: conda-incubator/setup-miniconda@v3
+        with:
+          miniforge-variant: Mambaforge
+          miniforge-version: latest
+          mamba-version: "*"
+          activate-environment: pytensor-test
+          channel-priority: strict
+          environment-file: environment.yml
+          python-version: "3.10"
+          use-mamba: true
+          use-only-tar-bz2: false # IMPORTANT: This may break caching of conda packages! See https://github.com/conda-incubator/setup-miniconda/issues/267
+      - name: Install-pytensor and mypy dependencies
+        run: |
+          conda activate pytensor-test
+          pip install -e .
+          python --version
+      - name: Run mypy
+        run: |
+          conda activate pytensor-test
+          python ./scripts/run_mypy.py --verbose
\ No newline at end of file
diff --git a/.pre-commit-config.yaml b/.pre-commit-config.yaml
index 7e3f04ccd4..68a0becbdc 100644
--- a/.pre-commit-config.yaml
+++ b/.pre-commit-config.yaml
@@ -27,17 +27,3 @@ repos:
       - id: ruff
         args: ["--fix", "--output-format=full"]
       - id: ruff-format
-  - repo: https://github.com/pre-commit/mirrors-mypy
-    rev: v1.10.0
-    hooks:
-      - id: mypy
-        language: python
-        entry: python ./scripts/run_mypy.py --verbose
-        additional_dependencies:
-        - numpy>=1.20
-        - pandas
-        - types-filelock
-        - types-setuptools>=67.6.0.8
-        always_run: true
-        require_serial: true
-        pass_filenames: false
diff --git a/environment.yml b/environment.yml
index 0e5d3387af..a50b9fcb29 100644
--- a/environment.yml
+++ b/environment.yml
@@ -26,6 +26,9 @@ dependencies:
   # For testing
   - coveralls
   - diff-cover
+  - mypy
+  - types-filelock
+  - types-setuptools
   - pytest
   - pytest-cov
   - pytest-xdist
@@ -41,6 +44,7 @@ dependencies:
   # code style
   - ruff
   # developer tools
+  - pandas # required to run mypy script
   - pre-commit
   - packaging
   - typing_extensions