diff --git a/doc/source/release.rst b/doc/source/release.rst
index 795c3cd642a80..8586f2093b9d2 100644
--- a/doc/source/release.rst
+++ b/doc/source/release.rst
@@ -533,6 +533,7 @@ Bug Fixes
 - Bug in ``query``/``eval`` where global constants were not looked up correctly
   (:issue:`7178`)
 - Bug in recognizing out-of-bounds positional list indexers with ``iloc`` and a multi-axis tuple indexer (:issue:`7189`)
+- Bug in setitem with a single value, multi-index and integer indices (:issue:`7190`)
 
 pandas 0.13.1
 -------------
diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index 5359a045451c3..cf8ad0f48a939 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -333,11 +333,7 @@ def _setitem_with_indexer(self, indexer, value):
                 obj = self.obj[item]
                 index = obj.index
                 idx = indexer[:info_axis][0]
-                try:
-                    if idx in index:
-                        idx = index.get_loc(idx)
-                except:
-                    pass
+
                 plane_indexer = tuple([idx]) + indexer[info_axis + 1:]
                 lplane_indexer = _length_of_indexer(plane_indexer[0], index)
 
diff --git a/pandas/tests/test_indexing.py b/pandas/tests/test_indexing.py
index db27f9be867c6..a2550810ef13d 100644
--- a/pandas/tests/test_indexing.py
+++ b/pandas/tests/test_indexing.py
@@ -607,6 +607,17 @@ def test_loc_setitem(self):
         expected = DataFrame({'a' : [0.5,-0.5,-1.5], 'b' : [0,1,2] })
         assert_frame_equal(df,expected)
 
+    def test_loc_setitem_multiindex(self):
+
+        # GH7190
+        index = pd.MultiIndex.from_product([np.arange(0,100), np.arange(0, 80)], names=['time', 'firm'])
+        df = DataFrame(np.nan,columns=['A', 'w', 'l', 'a', 'x', 'X', 'd', 'profit'], index=index)
+        t, n = 0, 2
+
+        df.loc[(t,n),'X'] = 0
+        result = df.loc[(t,n),'X']
+        self.assertEqual(result, 0)
+
     def test_loc_setitem_dups(self):
 
         # GH 6541