diff --git a/doc/source/release.rst b/doc/source/release.rst
index 798adf5504f1e..aa852c4416ade 100644
--- a/doc/source/release.rst
+++ b/doc/source/release.rst
@@ -183,6 +183,7 @@ Bug Fixes
 - Bug in ``io.data.DataReader`` when passed ``"F-F_Momentum_Factor"`` and ``data_source="famafrench"`` (:issue:`6460`)
 - Bug in ``sum`` of a ``timedelta64[ns]`` series (:issue:`6462`)
 - Bug in ``resample`` with a timezone and certain offsets (:issue:`6397`)
+- Bug in ``iat/iloc`` with duplicate indices on a Series (:issue:`6493`)
 
 pandas 0.13.1
 -------------
diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index fad348aed0c7d..e8d106dcfda77 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -1519,7 +1519,7 @@ def _unpickle_matrix_compat(self, state):  # pragma: no cover
     #----------------------------------------------------------------------
     # Getting and setting elements
 
-    def get_value(self, index, col):
+    def get_value(self, index, col, takeable=False):
         """
         Quickly retrieve single value at passed column and index
 
@@ -1527,16 +1527,22 @@ def get_value(self, index, col):
         ----------
         index : row label
         col : column label
+        takeable : interpret the index/col as indexers, default False
 
         Returns
         -------
         value : scalar value
         """
+
+        if takeable is True:
+            series = self._iget_item_cache(col)
+            return series.values[index]
+
         series = self._get_item_cache(col)
         engine = self.index._engine
         return engine.get_value(series.values, index)
 
-    def set_value(self, index, col, value):
+    def set_value(self, index, col, value, takeable=False):
         """
         Put single value at passed column and index
 
@@ -1545,6 +1551,7 @@ def set_value(self, index, col, value):
         index : row label
         col : column label
         value : scalar value
+        takeable : interpret the index/col as indexers, default False
 
         Returns
         -------
@@ -1553,6 +1560,10 @@ def set_value(self, index, col, value):
             otherwise a new object
         """
         try:
+            if takeable is True:
+                series = self._iget_item_cache(col)
+                return series.set_value(index, value, takeable=True)
+
             series = self._get_item_cache(col)
             engine = self.index._engine
             engine.set_value(series.values, index, value)
diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index 811604432a018..b7bcd5578bdbf 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -1004,6 +1004,7 @@ def __getitem__(self, item):
         return self._get_item_cache(item)
 
     def _get_item_cache(self, item):
+        """ return the cached item, item represents a label indexer """
         cache = self._item_cache
         res = cache.get(item)
         if res is None:
@@ -1021,6 +1022,15 @@ def _set_as_cached(self, item, cacher):
             a weakref to cacher """
         self._cacher = (item, weakref.ref(cacher))
 
+    def _iget_item_cache(self, item):
+        """ return the cached item, item represents a positional indexer """
+        ax = self._info_axis
+        if ax.is_unique:
+            lower = self._get_item_cache(ax[item])
+        else:
+            lower = self.take(item, axis=self._info_axis_number, convert=True)
+        return lower
+
     def _box_item_values(self, key, values):
         raise NotImplementedError
 
@@ -1595,7 +1605,8 @@ def _reindex_axes(self, axes, level, limit, method, fill_value, copy,
 
             obj = obj._reindex_with_indexers(
                 {axis: [new_index, indexer]}, method=method,
-                fill_value=fill_value, limit=limit, copy=copy)
+                fill_value=fill_value, limit=limit, copy=copy,
+                allow_dups=takeable)
 
         return obj
 
diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index 40c6091df64ab..662213c447688 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -1419,7 +1419,7 @@ def __getitem__(self, key):
                 raise ValueError('Invalid call for scalar access (getting)!')
 
         key = self._convert_key(key)
-        return self.obj.get_value(*key)
+        return self.obj.get_value(*key, takeable=self._takeable)
 
     def __setitem__(self, key, value):
         if not isinstance(key, tuple):
@@ -1427,33 +1427,32 @@ def __setitem__(self, key, value):
         if len(key) != self.obj.ndim:
             raise ValueError('Not enough indexers for scalar access '
                              '(setting)!')
-        key = self._convert_key(key)
+        key = list(self._convert_key(key))
         key.append(value)
-        self.obj.set_value(*key)
+        self.obj.set_value(*key, takeable=self._takeable)
 
 
 class _AtIndexer(_ScalarAccessIndexer):
 
     """ label based scalar accessor """
-    pass
+    _takeable = False
 
 
 class _iAtIndexer(_ScalarAccessIndexer):
 
     """ integer based scalar accessor """
+    _takeable = True
 
     def _has_valid_setitem_indexer(self, indexer):
         self._has_valid_positional_setitem_indexer(indexer)
 
     def _convert_key(self, key):
         """ require  integer args (and convert to label arguments) """
-        ckey = []
         for a, i in zip(self.obj.axes, key):
             if not com.is_integer(i):
                 raise ValueError("iAt based indexing can only have integer "
                                  "indexers")
-            ckey.append(a[i])
-        return ckey
+        return key
 
 # 32-bit floating point machine epsilon
 _eps = np.finfo('f4').eps
diff --git a/pandas/core/panel.py b/pandas/core/panel.py
index cb149abb7c9cf..eba526f574375 100644
--- a/pandas/core/panel.py
+++ b/pandas/core/panel.py
@@ -444,7 +444,7 @@ def as_matrix(self):
     #----------------------------------------------------------------------
     # Getting and setting elements
 
-    def get_value(self, *args):
+    def get_value(self, *args, **kwargs):
         """
         Quickly retrieve single value at (item, major, minor) location
 
@@ -453,6 +453,7 @@ def get_value(self, *args):
         item : item label (panel item)
         major : major axis label (panel item row)
         minor : minor axis label (panel item column)
+        takeable : interpret the passed labels as indexers, default False
 
         Returns
         -------
@@ -466,12 +467,16 @@ def get_value(self, *args):
             raise TypeError('There must be an argument for each axis, you gave'
                             ' {0} args, but {1} are required'.format(nargs,
                                                                      nreq))
+        takeable = kwargs.get('takeable')
 
-        # hm, two layers to the onion
-        frame = self._get_item_cache(args[0])
-        return frame.get_value(*args[1:])
+        if takeable is True:
+            lower = self._iget_item_cache(args[0])
+        else:
+            lower = self._get_item_cache(args[0])
+
+        return lower.get_value(*args[1:], takeable=takeable)
 
-    def set_value(self, *args):
+    def set_value(self, *args, **kwargs):
         """
         Quickly set single value at (item, major, minor) location
 
@@ -481,6 +486,7 @@ def set_value(self, *args):
         major : major axis label (panel item row)
         minor : minor axis label (panel item column)
         value : scalar
+        takeable : interpret the passed labels as indexers, default False
 
         Returns
         -------
@@ -496,10 +502,15 @@ def set_value(self, *args):
             raise TypeError('There must be an argument for each axis plus the '
                             'value provided, you gave {0} args, but {1} are '
                             'required'.format(nargs, nreq))
+        takeable = kwargs.get('takeable')
 
         try:
-            frame = self._get_item_cache(args[0])
-            frame.set_value(*args[1:])
+            if takeable is True:
+                lower = self._iget_item_cache(args[0])
+            else:
+                lower = self._get_item_cache(args[0])
+
+            lower.set_value(*args[1:], takeable=takeable)
             return self
         except KeyError:
             axes = self._expand_axes(args)
diff --git a/pandas/core/series.py b/pandas/core/series.py
index cd5b8ed5e4efd..3d5c97e8a5ac4 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -725,21 +725,24 @@ def reshape(self, *args, **kwargs):
     iget = _ixs
     irow = _ixs
 
-    def get_value(self, label):
+    def get_value(self, label, takeable=False):
         """
         Quickly retrieve single value at passed index label
 
         Parameters
         ----------
         index : label
+        takeable : interpret the index as indexers, default False
 
         Returns
         -------
         value : scalar value
         """
+        if takeable is True:
+            return self.values[label]
         return self.index.get_value(self.values, label)
 
-    def set_value(self, label, value):
+    def set_value(self, label, value, takeable=False):
         """
         Quickly set single value at passed label. If label is not contained, a
         new object is created with the label placed at the end of the result
@@ -751,6 +754,7 @@ def set_value(self, label, value):
             Partial indexing with MultiIndex not allowed
         value : object
             Scalar value
+        takeable : interpret the index as indexers, default False
 
         Returns
         -------
@@ -759,7 +763,10 @@ def set_value(self, label, value):
             otherwise a new object
         """
         try:
-            self.index._engine.set_value(self.values, label, value)
+            if takeable:
+                self.values[label] = value
+            else:
+                self.index._engine.set_value(self.values, label, value)
             return self
         except KeyError:
 
diff --git a/pandas/sparse/frame.py b/pandas/sparse/frame.py
index deb9065a2b5a6..6e76155619c09 100644
--- a/pandas/sparse/frame.py
+++ b/pandas/sparse/frame.py
@@ -346,10 +346,15 @@ def __getitem__(self, key):
             return self._get_item_cache(key)
 
     @Appender(DataFrame.get_value.__doc__, indents=0)
-    def get_value(self, index, col):
-        return self._get_item_cache(col).get_value(index)
+    def get_value(self, index, col, takeable=False):
+        if takeable is True:
+            series = self._iget_item_cache(col)
+        else:
+            series = self._get_item_cache(col)
+
+        return series.get_value(index, takeable=takeable)
 
-    def set_value(self, index, col, value):
+    def set_value(self, index, col, value, takeable=False):
         """
         Put single value at passed column and index
 
@@ -358,6 +363,7 @@ def set_value(self, index, col, value):
         index : row label
         col : column label
         value : scalar value
+        takeable : interpret the index/col as indexers, default False
 
         Notes
         -----
@@ -369,7 +375,7 @@ def set_value(self, index, col, value):
         -------
         frame : DataFrame
         """
-        dense = self.to_dense().set_value(index, col, value)
+        dense = self.to_dense().set_value(index, col, value, takeable=takeable)
         return dense.to_sparse(kind=self._default_kind,
                                fill_value=self._default_fill_value)
 
diff --git a/pandas/sparse/series.py b/pandas/sparse/series.py
index cf4060fa6d871..1c599653f9fc5 100644
--- a/pandas/sparse/series.py
+++ b/pandas/sparse/series.py
@@ -409,22 +409,23 @@ def get(self, label, default=None):
         else:
             return default
 
-    def get_value(self, label):
+    def get_value(self, label, takeable=False):
         """
         Retrieve single value at passed index label
 
         Parameters
         ----------
         index : label
+        takeable : interpret the index as indexers, default False
 
         Returns
         -------
         value : scalar value
         """
-        loc = self.index.get_loc(label)
+        loc = label if takeable is True else self.index.get_loc(label)
         return self._get_val_at(loc)
 
-    def set_value(self, label, value):
+    def set_value(self, label, value, takeable=False):
         """
         Quickly set single value at passed label. If label is not contained, a
         new object is created with the label placed at the end of the result
@@ -436,6 +437,7 @@ def set_value(self, label, value):
             Partial indexing with MultiIndex not allowed
         value : object
             Scalar value
+        takeable : interpret the index as indexers, default False
 
         Notes
         -----
@@ -450,7 +452,7 @@ def set_value(self, label, value):
 
         # if the label doesn't exist, we will create a new object here
         # and possibily change the index
-        new_values = values.set_value(label, value)
+        new_values = values.set_value(label, value, takeable=takeable)
         if new_values is not None:
             values = new_values
         new_index = values.index
diff --git a/pandas/tests/test_indexing.py b/pandas/tests/test_indexing.py
index 3111309acff48..9c228c8654c44 100644
--- a/pandas/tests/test_indexing.py
+++ b/pandas/tests/test_indexing.py
@@ -334,6 +334,33 @@ def test_at_timestamp(self):
     def test_iat_invalid_args(self):
         pass
 
+    def test_imethods_with_dups(self):
+
+        # GH6493
+        # iat/iloc with dups
+
+        s = Series(range(5), index=[1,1,2,2,3])
+        result = s.iloc[2]
+        self.assertEqual(result,2)
+        result = s.iat[2]
+        self.assertEqual(result,2)
+
+        self.assertRaises(IndexError, lambda : s.iat[10])
+        self.assertRaises(IndexError, lambda : s.iat[-10])
+
+        result = s.iloc[[2,3]]
+        expected = Series([2,3],[2,2],dtype='int64')
+        assert_series_equal(result,expected)
+
+        df = s.to_frame()
+        result = df.iloc[2]
+        expected = Series(2,index=[0])
+        assert_series_equal(result,expected)
+
+        result = df.iat[2,0]
+        expected = 2
+        self.assertEqual(result,2)
+
     def test_repeated_getitem_dups(self):
         # GH 5678
         # repeated gettitems on a dup index returing a ndarray