diff --git a/doc/source/user_guide/entry_points.rst b/doc/source/user_guide/entry_points.rst
new file mode 100644
index 0000000000000..1333ed77b7e1e
--- /dev/null
+++ b/doc/source/user_guide/entry_points.rst
@@ -0,0 +1 @@
+TODO
diff --git a/doc/source/whatsnew/v3.0.0.rst b/doc/source/whatsnew/v3.0.0.rst
index 8695e196c4f38..b5c22a949d9f5 100644
--- a/doc/source/whatsnew/v3.0.0.rst
+++ b/doc/source/whatsnew/v3.0.0.rst
@@ -83,6 +83,7 @@ Other enhancements
 - Improved deprecation message for offset aliases (:issue:`60820`)
 - Multiplying two :class:`DateOffset` objects will now raise a ``TypeError`` instead of a ``RecursionError`` (:issue:`59442`)
 - Restore support for reading Stata 104-format and enable reading 103-format dta files (:issue:`58554`)
+- Support :class:`DataFrame` plugin accessor via entry points (:issue:`29076`)
 - Support passing a :class:`Iterable[Hashable]` input to :meth:`DataFrame.drop_duplicates` (:issue:`59237`)
 - Support reading Stata 102-format (Stata 1) dta files (:issue:`58978`)
 - Support reading Stata 110-format (Stata 7) dta files (:issue:`47176`)
diff --git a/pandas/__init__.py b/pandas/__init__.py
index 7d6dd7b7c1a88..6f1c6e1e7cc56 100644
--- a/pandas/__init__.py
+++ b/pandas/__init__.py
@@ -346,3 +346,8 @@
     "unique",
     "wide_to_long",
 ]
+
+from pandas.core.accessor import DataFrameAccessorLoader
+
+DataFrameAccessorLoader.load()
+del DataFrameAccessorLoader
diff --git a/pandas/core/accessor.py b/pandas/core/accessor.py
index 0331c26c805b6..ba600926c3841 100644
--- a/pandas/core/accessor.py
+++ b/pandas/core/accessor.py
@@ -10,6 +10,7 @@
 import functools
 from typing import (
     TYPE_CHECKING,
+    Any,
     final,
 )
 import warnings
@@ -25,6 +26,8 @@
     from pandas import Index
     from pandas.core.generic import NDFrame
 
+from importlib.metadata import entry_points
+
 
 class DirNamesMixin:
     _accessors: set[str] = set()
@@ -393,3 +396,39 @@ def register_index_accessor(name: str) -> Callable[[TypeT], TypeT]:
     from pandas import Index
 
     return _register_accessor(name, Index)
+
+
+class DataFrameAccessorLoader:
+    """Loader class for registering DataFrame accessors via entry points."""
+
+    ENTRY_POINT_GROUP: str = "pandas_dataframe_accessor"
+
+    @classmethod
+    def load(cls) -> None:
+        """loads and registers accessors defined by 'pandas_dataframe_accessor'."""
+        eps = entry_points(group=cls.ENTRY_POINT_GROUP)
+        names: set[str] = set()
+
+        for ep in eps:
+            name: str = ep.name
+
+            if name in names:  # Verifies duplicated package names
+                warnings.warn(
+                    f"Warning: you have two packages with the same name: '{name}'. "
+                    "Uninstall the package you don't want to use "
+                    "in order to remove this warning.\n",
+                    UserWarning,
+                    stacklevel=2,
+                )
+
+            else:
+                names.add(name)
+
+            def make_property(ep):
+                def accessor(self) -> Any:
+                    cls_ = ep.load()
+                    return cls_(self)
+
+                return accessor
+
+            register_dataframe_accessor(name)(make_property(ep))
diff --git a/pandas/tests/test_plugis_entrypoint_loader.py b/pandas/tests/test_plugis_entrypoint_loader.py
new file mode 100644
index 0000000000000..d292257f6cad8
--- /dev/null
+++ b/pandas/tests/test_plugis_entrypoint_loader.py
@@ -0,0 +1,227 @@
+import pandas as pd
+import pandas._testing as tm
+from pandas.core.accessor import DataFrameAccessorLoader
+
+
+def test_no_accessors(monkeypatch):
+    # GH29076
+
+    # Mock entry_points
+    def mock_entry_points(*, group):
+        return []
+
+    # Patch entry_points in the correct module
+    monkeypatch.setattr("pandas.core.accessor.entry_points", mock_entry_points)
+
+    DataFrameAccessorLoader.load()
+
+
+def test_load_dataframe_accessors(monkeypatch):
+    # GH29076
+    # Mocked EntryPoint to simulate a plugin
+    class MockEntryPoint:
+        name = "test_accessor"
+
+        def load(self):
+            class TestAccessor:
+                def __init__(self, df):
+                    self._df = df
+
+                def test_method(self):
+                    return "success"
+
+            return TestAccessor
+
+    # Mock entry_points
+    def mock_entry_points(*, group):
+        if group == DataFrameAccessorLoader.ENTRY_POINT_GROUP:
+            return [MockEntryPoint()]
+        return []
+
+    # Patch entry_points in the correct module
+    monkeypatch.setattr("pandas.core.accessor.entry_points", mock_entry_points)
+
+    DataFrameAccessorLoader.load()
+
+    # Create DataFrame and verify that the accessor was registered
+    df = pd.DataFrame({"a": [1, 2, 3]})
+    assert hasattr(df, "test_accessor")
+    assert df.test_accessor.test_method() == "success"
+
+
+def test_duplicate_accessor_names(monkeypatch):
+    # GH29076
+    # Create plugin
+    class MockEntryPoint1:
+        name = "duplicate_accessor"
+
+        def load(self):
+            class Accessor1:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor1"
+
+            return Accessor1
+
+    # Create plugin
+    class MockEntryPoint2:
+        name = "duplicate_accessor"
+
+        def load(self):
+            class Accessor2:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor2"
+
+            return Accessor2
+
+    def mock_entry_points(*, group):
+        if group == DataFrameAccessorLoader.ENTRY_POINT_GROUP:
+            return [MockEntryPoint1(), MockEntryPoint2()]
+        return []
+
+    monkeypatch.setattr("pandas.core.accessor.entry_points", mock_entry_points)
+
+    # Check that the UserWarning is raised
+    with tm.assert_produces_warning(UserWarning, match="duplicate_accessor") as record:
+        DataFrameAccessorLoader.load()
+
+    messages = [str(w.message) for w in record]
+    assert any("two packages with the same name" in msg for msg in messages)
+
+    df = pd.DataFrame({"x": [1, 2, 3]})
+    assert hasattr(df, "duplicate_accessor")
+    assert df.duplicate_accessor.which() in {"Accessor1", "Accessor2"}
+
+
+def test_unique_accessor_names(monkeypatch):
+    # GH29076
+    # Create plugin
+    class MockEntryPoint1:
+        name = "accessor1"
+
+        def load(self):
+            class Accessor1:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor1"
+
+            return Accessor1
+
+    # Create plugin
+    class MockEntryPoint2:
+        name = "accessor2"
+
+        def load(self):
+            class Accessor2:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor2"
+
+            return Accessor2
+
+    def mock_entry_points(*, group):
+        if group == DataFrameAccessorLoader.ENTRY_POINT_GROUP:
+            return [MockEntryPoint1(), MockEntryPoint2()]
+        return []
+
+    monkeypatch.setattr("pandas.core.accessor.entry_points", mock_entry_points)
+
+    # Check that no UserWarning is raised
+    with tm.assert_produces_warning(None, check_stacklevel=False):
+        DataFrameAccessorLoader.load()
+
+    df = pd.DataFrame({"x": [1, 2, 3]})
+    assert hasattr(df, "accessor1"), "Accessor1 not registered"
+    assert hasattr(df, "accessor2"), "Accessor2 not registered"
+    assert df.accessor1.which() == "Accessor1", "Accessor1 method incorrect"
+    assert df.accessor2.which() == "Accessor2", "Accessor2 method incorrect"
+
+
+def test_duplicate_and_unique_accessor_names(monkeypatch):
+    # GH29076
+    # Create plugin
+    class MockEntryPoint1:
+        name = "duplicate_accessor"
+
+        def load(self):
+            class Accessor1:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor1"
+
+            return Accessor1
+
+    # Create plugin
+    class MockEntryPoint2:
+        name = "duplicate_accessor"
+
+        def load(self):
+            class Accessor2:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor2"
+
+            return Accessor2
+
+    # Create plugin
+    class MockEntryPoint3:
+        name = "unique_accessor"
+
+        def load(self):
+            class Accessor3:
+                def __init__(self, df):
+                    self._df = df
+
+                def which(self):
+                    return "Accessor3"
+
+            return Accessor3
+
+    def mock_entry_points(*, group):
+        if group == DataFrameAccessorLoader.ENTRY_POINT_GROUP:
+            return [MockEntryPoint1(), MockEntryPoint2(), MockEntryPoint3()]
+        return []
+
+    monkeypatch.setattr("pandas.core.accessor.entry_points", mock_entry_points)
+
+    # Capture warnings
+    with tm.assert_produces_warning(UserWarning, match="duplicate_accessor") as record:
+        DataFrameAccessorLoader.load()
+
+    messages = [str(w.message) for w in record]
+
+    # Filter warnings for the specific message about duplicate packages
+    duplicate_package_warnings = [
+        msg
+        for msg in messages
+        if "you have two packages with the same name: 'duplicate_accessor'" in msg
+    ]
+
+    # Assert one warning about duplicate packages
+    assert len(duplicate_package_warnings) == 1, (
+        f"Expected exactly one warning about duplicate packages, "
+        f"got {len(duplicate_package_warnings)}: {duplicate_package_warnings}"
+    )
+
+    df = pd.DataFrame({"x": [1, 2, 3]})
+    assert hasattr(df, "duplicate_accessor"), "duplicate_accessor not registered"
+
+    assert hasattr(df, "unique_accessor"), "unique_accessor not registered"
+
+    assert df.duplicate_accessor.which() in {"Accessor1", "Accessor2"}, (
+        "duplicate_accessor method incorrect"
+    )
+    assert df.unique_accessor.which() == "Accessor3", "unique_accessor method incorrect"