diff --git a/doc/source/whatsnew/v3.0.0.rst b/doc/source/whatsnew/v3.0.0.rst
index 9e7349a061295..4a6606ed20df2 100644
--- a/doc/source/whatsnew/v3.0.0.rst
+++ b/doc/source/whatsnew/v3.0.0.rst
@@ -38,12 +38,7 @@ Other enhancements
 - Support reading value labels from Stata 108-format (Stata 6) and earlier files (:issue:`58154`)
 - Users can globally disable any ``PerformanceWarning`` by setting the option ``mode.performance_warnings`` to ``False`` (:issue:`56920`)
 - :meth:`Styler.format_index_names` can now be used to format the index and column names (:issue:`48936` and :issue:`47489`)
-- :class:`.errors.DtypeWarning` improved to include column names when mixed data types are detected (:issue:`58174`)
-- :meth:`DataFrame.corrwith` now accepts ``min_periods`` as optional arguments, as in :meth:`DataFrame.corr` and :meth:`Series.corr` (:issue:`9490`)
-- :meth:`DataFrame.cummin`, :meth:`DataFrame.cummax`, :meth:`DataFrame.cumprod` and :meth:`DataFrame.cumsum` methods now have a ``numeric_only`` parameter (:issue:`53072`)
-- :meth:`DataFrame.fillna` and :meth:`Series.fillna` can now accept ``value=None``; for non-object dtype the corresponding NA value will be used (:issue:`57723`)
-- :meth:`Series.cummin` and :meth:`Series.cummax` now supports :class:`CategoricalDtype` (:issue:`52335`)
-- :meth:`Series.plot` now correctly handle the ``ylabel`` parameter for pie charts, allowing for explicit control over the y-axis label (:issue:`58239`)
+- Added new display.option for integer formatting within DataFrames (:issue:`57177`)
 
 .. ---------------------------------------------------------------------------
 .. _whatsnew_300.notable_bug_fixes:
diff --git a/pandas/core/config_init.py b/pandas/core/config_init.py
index 46c9139c3456c..38138ce9c663c 100644
--- a/pandas/core/config_init.py
+++ b/pandas/core/config_init.py
@@ -276,6 +276,12 @@ def use_numba_cb(key: str) -> None:
     df.info() is called. Valid values True,False,'deep'
 """
 
+pc_integer_format_doc = """
+:   str
+    This formats integer values in a DataFrame with a delimiter that defaults
+    to None (''). The other two options are 'comma' (',') and 'underscore' ('_').
+"""
+
 
 def table_schema_cb(key: str) -> None:
     from pandas.io.formats.printing import enable_data_resource_formatter
@@ -388,6 +394,12 @@ def is_terminal() -> bool:
     cf.register_option(
         "max_dir_items", 100, pc_max_dir_items, validator=is_nonnegative_int
     )
+    cf.register_option(
+        "integer_format",
+        None,
+        pc_integer_format_doc,
+        validator=is_instance_factory((type(None), str)),
+    )
 
 tc_sim_interactive_doc = """
 : boolean
@@ -412,9 +424,11 @@ def is_terminal() -> bool:
         "copy_on_write",
         # Get the default from an environment variable, if set, otherwise defaults
         # to False. This environment variable can be set for testing.
-        "warn"
-        if os.environ.get("PANDAS_COPY_ON_WRITE", "0") == "warn"
-        else os.environ.get("PANDAS_COPY_ON_WRITE", "0") == "1",
+        (
+            "warn"
+            if os.environ.get("PANDAS_COPY_ON_WRITE", "0") == "warn"
+            else os.environ.get("PANDAS_COPY_ON_WRITE", "0") == "1"
+        ),
         copy_on_write_doc,
         validator=is_one_of_factory([True, False, "warn"]),
     )
diff --git a/pandas/io/formats/format.py b/pandas/io/formats/format.py
index c503121328f53..2c914b2028bdc 100644
--- a/pandas/io/formats/format.py
+++ b/pandas/io/formats/format.py
@@ -434,6 +434,7 @@ def __init__(
         formatters: FormattersType | None = None,
         justify: str | None = None,
         float_format: FloatFormatType | None = None,
+        integer_format: str | None = None,
         sparsify: bool | None = None,
         index_names: bool = True,
         max_rows: int | None = None,
@@ -453,6 +454,7 @@ def __init__(
         self.formatters = self._initialize_formatters(formatters)
         self.justify = self._initialize_justify(justify)
         self.float_format = float_format
+        self.integer_format = integer_format
         self.sparsify = self._initialize_sparsify(sparsify)
         self.show_index_names = index_names
         self.decimal = decimal
@@ -756,6 +758,7 @@ def format_col(self, i: int) -> list[str]:
             frame.iloc[:, i]._values,
             formatter,
             float_format=self.float_format,
+            integer_format=self.integer_format,
             na_rep=self.na_rep,
             space=self.col_space.get(frame.columns[i]),
             decimal=self.decimal,
@@ -789,9 +792,11 @@ def _get_formatted_column_labels(self, frame: DataFrame) -> list[list[str]]:
             fmt_columns = columns._format_flat(include_name=False)
             str_columns = [
                 [
-                    " " + x
-                    if not self._get_formatter(i) and is_numeric_dtype(dtype)
-                    else x
+                    (
+                        " " + x
+                        if not self._get_formatter(i) and is_numeric_dtype(dtype)
+                        else x
+                    )
                 ]
                 for i, (x, dtype) in enumerate(zip(fmt_columns, self.frame.dtypes))
             ]
@@ -1063,6 +1068,7 @@ def format_array(
     values: ArrayLike,
     formatter: Callable | None,
     float_format: FloatFormatType | None = None,
+    integer_format: str | None = None,
     na_rep: str = "NaN",
     digits: int | None = None,
     space: str | int | None = None,
@@ -1124,6 +1130,9 @@ def format_array(
     if float_format is None:
         float_format = get_option("display.float_format")
 
+    if integer_format is None:
+        integer_format = get_option("display.integer_format")
+
     if digits is None:
         digits = get_option("display.precision")
 
@@ -1132,6 +1141,7 @@ def format_array(
         digits=digits,
         na_rep=na_rep,
         float_format=float_format,
+        integer_format=integer_format,
         formatter=formatter,
         space=space,
         justify=justify,
@@ -1153,6 +1163,7 @@ def __init__(
         na_rep: str = "NaN",
         space: str | int = 12,
         float_format: FloatFormatType | None = None,
+        integer_format: str | None = None,
         justify: str = "right",
         decimal: str = ".",
         quoting: int | None = None,
@@ -1166,6 +1177,7 @@ def __init__(
         self.space = space
         self.formatter = formatter
         self.float_format = float_format
+        self.integer_format = integer_format
         self.justify = justify
         self.decimal = decimal
         self.quoting = quoting
@@ -1455,13 +1467,19 @@ def _format_strings(self) -> list[str]:
 
 class _IntArrayFormatter(_GenericArrayFormatter):
     def _format_strings(self) -> list[str]:
-        if self.leading_space is False:
-            formatter_str = lambda x: f"{x:d}".format(x=x)
+
+        if self.integer_format in (",", "_", None):
+            if self.integer_format is None:
+                self.integer_format = ""
+            if self.leading_space is False:
+                formatter_str = lambda x: f"{x:{self.integer_format}}".format(x=x)
+            else:
+                formatter_str = lambda x: f"{x: {self.integer_format}}".format(x=x)
+            formatter = self.formatter or formatter_str
+            fmt_values = [formatter(x) for x in self.values]
+            return fmt_values
         else:
-            formatter_str = lambda x: f"{x: d}".format(x=x)
-        formatter = self.formatter or formatter_str
-        fmt_values = [formatter(x) for x in self.values]
-        return fmt_values
+            raise ValueError("integer_format must be one of ',','_', or None")
 
 
 class _Datetime64Formatter(_GenericArrayFormatter):
diff --git a/pandas/tests/io/formats/test_format.py b/pandas/tests/io/formats/test_format.py
index b12cfc6876a8e..07c8bb06f6d75 100644
--- a/pandas/tests/io/formats/test_format.py
+++ b/pandas/tests/io/formats/test_format.py
@@ -2259,3 +2259,69 @@ def test_filepath_or_buffer_bad_arg_raises(float_frame, method):
     msg = "buf is not a file name and it has no write method"
     with pytest.raises(TypeError, match=msg):
         getattr(float_frame, method)(buf=object())
+
+
+class TestIntArrayFormatter:
+    def test_format_comma(self):
+        with option_context("display.integer_format", ","):
+            df = DataFrame({"A": [1000, 20000, 30], "B": [4.1, 50000.2, 600.0]})
+            formatted_df = repr(df)
+            # Valid delimiter used for integer_format
+            expected_results = {
+                "A": ["1,000", "20,000", "30"],
+                "B": ["4.1", "50000.2", "600.0"],
+            }
+            expected_df = DataFrame(expected_results)
+            expected_df = repr(expected_df)
+
+            assert formatted_df == expected_df
+
+    def test_format_underscore(self):
+        with option_context("display.integer_format", "_"):
+            df = DataFrame({"A": [1000, 20000, 30], "B": [4.1, 50000.2, 600.0]})
+            formatted_df = repr(df)
+            # Valid delimiter used for integer_format
+            expected_results = {
+                "A": ["1_000", "20_000", "30"],
+                "B": ["4.1", "50000.2", "600.0"],
+            }
+            expected_df = DataFrame(expected_results)
+            expected_df = repr(expected_df)
+
+            assert formatted_df == expected_df
+
+    def test_format_empty(self):
+        with option_context("display.integer_format", None):
+            df = DataFrame({"A": [1000, 20000, 30], "B": [4.1, 50000.2, 600.0]})
+            formatted_df = repr(df)
+            # Valid delimiter used for integer_format
+            expected_results = {
+                "A": ["1000", "20000", "30"],
+                "B": ["4.1", "50000.2", "600.0"],
+            }
+            expected_df = DataFrame(expected_results)
+            expected_df = repr(expected_df)
+
+            assert formatted_df == expected_df
+
+    def test_format_invalid_to_none(self):
+        with option_context("display.integer_format", "."):
+            df = DataFrame({"A": [1000, 20000, 30], "B": [4.1, 50000.2, 600.0]})
+
+            with pytest.raises(
+                ValueError, match="integer_format must be one of ',','_', or None"
+            ):
+                repr(df)
+
+        with option_context("display.integer_format", None):
+            df = DataFrame({"A": [1000, 20000, 30], "B": [4.1, 50000.2, 600.0]})
+            formatted_df = repr(df)
+            # Valid delimiter used for integer_format
+            expected_results = {
+                "A": ["1000", "20000", "30"],
+                "B": ["4.1", "50000.2", "600.0"],
+            }
+            expected_df = DataFrame(expected_results)
+            expected_df = repr(expected_df)
+
+            assert formatted_df == expected_df