diff --git a/pandas/tests/tseries/holiday/test_holiday.py b/pandas/tests/tseries/holiday/test_holiday.py
index b2eefd04ef93b..08f4a1250392e 100644
--- a/pandas/tests/tseries/holiday/test_holiday.py
+++ b/pandas/tests/tseries/holiday/test_holiday.py
@@ -271,6 +271,25 @@ def test_both_offset_observance_raises():
         )
 
 
+def test_list_of_list_of_offsets_raises():
+    # see gh-29049
+    # Test that the offsets of offsets are forbidden
+    holiday1 = Holiday(
+        "Holiday1",
+        month=USThanksgivingDay.month,
+        day=USThanksgivingDay.day,
+        offset=[USThanksgivingDay.offset, DateOffset(1)],
+    )
+    msg = "Only BaseOffsets and flat lists of them are supported for offset."
+    with pytest.raises(ValueError, match=msg):
+        Holiday(
+            "Holiday2",
+            month=holiday1.month,
+            day=holiday1.day,
+            offset=[holiday1.offset, DateOffset(3)],
+        )
+
+
 def test_half_open_interval_with_observance():
     # Prompted by GH 49075
     # Check for holidays that have a half-open date interval where
diff --git a/pandas/tseries/holiday.py b/pandas/tseries/holiday.py
index cc9e2e3be8c38..8e51183138b5c 100644
--- a/pandas/tseries/holiday.py
+++ b/pandas/tseries/holiday.py
@@ -4,6 +4,7 @@
     datetime,
     timedelta,
 )
+from typing import Callable
 import warnings
 
 from dateutil.relativedelta import (
@@ -17,6 +18,7 @@
 )
 import numpy as np
 
+from pandas._libs.tslibs.offsets import BaseOffset
 from pandas.errors import PerformanceWarning
 
 from pandas import (
@@ -159,24 +161,34 @@ def __init__(
         year=None,
         month=None,
         day=None,
-        offset=None,
-        observance=None,
+        offset: BaseOffset | list[BaseOffset] | None = None,
+        observance: Callable | None = None,
         start_date=None,
         end_date=None,
-        days_of_week=None,
+        days_of_week: tuple | None = None,
     ) -> None:
         """
         Parameters
         ----------
         name : str
             Name of the holiday , defaults to class name
-        offset : array of pandas.tseries.offsets or
-                class from pandas.tseries.offsets
-            computes offset from date
-        observance: function
-            computes when holiday is given a pandas Timestamp
-        days_of_week:
-            provide a tuple of days e.g  (0,1,2,3,) for Monday Through Thursday
+        year : int, default None
+            Year of the holiday
+        month : int, default None
+            Month of the holiday
+        day : int, default None
+            Day of the holiday
+        offset : list of pandas.tseries.offsets or
+                class from pandas.tseries.offsets, default None
+            Computes offset from date
+        observance : function, default None
+            Computes when holiday is given a pandas Timestamp
+        start_date : datetime-like, default None
+            First date the holiday is observed
+        end_date : datetime-like, default None
+            Last date the holiday is observed
+        days_of_week : tuple of int or dateutil.relativedelta weekday strs, default None
+            Provide a tuple of days e.g  (0,1,2,3,) for Monday Through Thursday
             Monday=0,..,Sunday=6
 
         Examples
@@ -216,8 +228,19 @@ class from pandas.tseries.offsets
         >>> July3rd
         Holiday: July 3rd (month=7, day=3, )
         """
-        if offset is not None and observance is not None:
-            raise NotImplementedError("Cannot use both offset and observance.")
+        if offset is not None:
+            if observance is not None:
+                raise NotImplementedError("Cannot use both offset and observance.")
+            if not (
+                isinstance(offset, BaseOffset)
+                or (
+                    isinstance(offset, list)
+                    and all(isinstance(off, BaseOffset) for off in offset)
+                )
+            ):
+                raise ValueError(
+                    "Only BaseOffsets and flat lists of them are supported for offset."
+                )
 
         self.name = name
         self.year = year