diff --git a/pandas/_libs/tslibs/timedeltas.pyx b/pandas/_libs/tslibs/timedeltas.pyx
index 28aeb854638b6..ffa9a67542e21 100644
--- a/pandas/_libs/tslibs/timedeltas.pyx
+++ b/pandas/_libs/tslibs/timedeltas.pyx
@@ -1843,7 +1843,10 @@ class Timedelta(_Timedelta):
                              NPY_DATETIMEUNIT.NPY_FR_W,
                              NPY_DATETIMEUNIT.NPY_FR_GENERIC]):
                 err = npy_unit_to_abbrev(reso)
-                raise ValueError(f" cannot construct a Timedelta from a unit {err}")
+                raise ValueError(
+                    f"Unit {err} is not supported. "
+                    "Only unambiguous timedelta values durations are supported. "
+                    "Allowed units are 'W', 'D', 'h', 'm', 's', 'ms', 'us', 'ns'")
 
             new_reso = get_supported_reso(reso)
             if reso != NPY_DATETIMEUNIT.NPY_FR_GENERIC:
diff --git a/pandas/tests/tslibs/test_timedeltas.py b/pandas/tests/tslibs/test_timedeltas.py
index 2308aa27b60ab..4784a6d0d600d 100644
--- a/pandas/tests/tslibs/test_timedeltas.py
+++ b/pandas/tests/tslibs/test_timedeltas.py
@@ -76,7 +76,10 @@ def test_delta_to_nanoseconds_td64_MY_raises():
 def test_unsupported_td64_unit_raises(unit):
     # GH 52806
     with pytest.raises(
-        ValueError, match=f"cannot construct a Timedelta from a unit {unit}"
+        ValueError,
+        match=f"Unit {unit} is not supported. "
+        "Only unambiguous timedelta values durations are supported. "
+        "Allowed units are 'W', 'D', 'h', 'm', 's', 'ms', 'us', 'ns'",
     ):
         Timedelta(np.timedelta64(1, unit))