diff --git a/pandas/core/indexing.py b/pandas/core/indexing.py
index 38bf6c34bf9c9..4a2803f638c73 100644
--- a/pandas/core/indexing.py
+++ b/pandas/core/indexing.py
@@ -400,6 +400,29 @@ def loc(self) -> _LocIndexer:
                     max_speed
         sidewinder          7
 
+        Multiple conditional using ``&`` that returns a boolean Series
+
+        >>> df.loc[(df['max_speed'] > 1) & (df['shield'] < 8)]
+               max_speed  shield
+        viper          4       5
+
+        Multiple conditional using ``|`` that returns a boolean Series
+
+        >>> df.loc[(df['max_speed'] > 4) | (df['shield'] < 5)]
+                    max_speed  shield
+        cobra               1       2
+        sidewinder          7       8
+
+        Please ensure that each condition is wrapped in parentheses ``()``.
+        See the :ref:`user guide<indexing.boolean>`
+        for more details and explanations of Boolean indexing.
+
+        .. note::
+            If you find yourself using 3 or more conditionals in ``.loc[]``,
+            consider using :ref:`advanced indexing<advanced.advanced_hierarchical>`.
+
+            See below for using ``.loc[]`` on MultiIndex DataFrames.
+
         Callable that returns a boolean Series
 
         >>> df.loc[lambda df: df['shield'] == 8]