diff --git a/pandas/tests/series/test_constructors.py b/pandas/tests/series/test_constructors.py
index 0a8341476dc56..8cfd0682e1f5d 100644
--- a/pandas/tests/series/test_constructors.py
+++ b/pandas/tests/series/test_constructors.py
@@ -2128,3 +2128,22 @@ def test_constructor(rand_series_with_duplicate_datetimeindex):
 def test_numpy_array(input_dict, expected):
     result = np.array([Series(input_dict)])
     tm.assert_numpy_array_equal(result, expected)
+
+
+def test_index_ordered_dict_keys():
+    # GH 22077
+
+    param_index = OrderedDict(
+        [
+            ((("a", "b"), ("c", "d")), 1),
+            ((("a", None), ("c", "d")), 2),
+        ]
+    )
+    series = Series([1, 2], index=param_index.keys())
+    expected = Series(
+        [1, 2],
+        index=MultiIndex.from_tuples(
+            [(("a", "b"), ("c", "d")), (("a", None), ("c", "d"))]
+        ),
+    )
+    tm.assert_series_equal(series, expected)