diff --git a/doc/source/whatsnew/v1.6.0.rst b/doc/source/whatsnew/v1.6.0.rst
index 67e65cfc26764..6eea5daa3ac3e 100644
--- a/doc/source/whatsnew/v1.6.0.rst
+++ b/doc/source/whatsnew/v1.6.0.rst
@@ -152,6 +152,7 @@ Interval
 Indexing
 ^^^^^^^^
 - Bug in :meth:`DataFrame.reindex` filling with wrong values when indexing columns and index for ``uint`` dtypes (:issue:`48184`)
+- Bug in :meth:`DataFrame.reindex` casting dtype to ``object`` when :class:`DataFrame` has single extension array column when re-indexing ``columns`` and ``index`` (:issue:`48190`)
 -
 
 Missing
diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index f91d15e1a6487..a6e58a0c90dc7 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -5345,6 +5345,11 @@ def _needs_reindex_multi(self, axes, method, level) -> bool_t:
             and method is None
             and level is None
             and not self._is_mixed_type
+            and not (
+                self.ndim == 2
+                and len(self.dtypes) == 1
+                and is_extension_array_dtype(self.dtypes.iloc[0])
+            )
         )
 
     def _reindex_multi(self, axes, copy, fill_value):
diff --git a/pandas/tests/frame/methods/test_reindex.py b/pandas/tests/frame/methods/test_reindex.py
index daa60be085fd8..a132519970721 100644
--- a/pandas/tests/frame/methods/test_reindex.py
+++ b/pandas/tests/frame/methods/test_reindex.py
@@ -782,6 +782,15 @@ def test_reindex_uint_dtypes_fill_value(self, any_unsigned_int_numpy_dtype):
         )
         tm.assert_frame_equal(result, expected)
 
+    def test_reindex_single_column_ea_index_and_columns(self, any_numeric_ea_dtype):
+        # GH#48190
+        df = DataFrame({"a": [1, 2]}, dtype=any_numeric_ea_dtype)
+        result = df.reindex(columns=list("ab"), index=[0, 1, 2], fill_value=10)
+        expected = DataFrame(
+            {"a": Series([1, 2, 10], dtype=any_numeric_ea_dtype), "b": 10}
+        )
+        tm.assert_frame_equal(result, expected)
+
     def test_reindex_dups(self):
 
         # GH4746, reindex on duplicate index error messages