diff --git a/asv_bench/benchmarks/io/excel.py b/asv_bench/benchmarks/io/excel.py
index a2d989e787e0f..a88c4374b7030 100644
--- a/asv_bench/benchmarks/io/excel.py
+++ b/asv_bench/benchmarks/io/excel.py
@@ -47,6 +47,25 @@ def time_write_excel(self, engine):
         writer.save()
 
 
+class WriteExcelStyled:
+    params = ["openpyxl", "xlsxwriter"]
+    param_names = ["engine"]
+
+    def setup(self, engine):
+        self.df = _generate_dataframe()
+
+    def time_write_excel_style(self, engine):
+        bio = BytesIO()
+        bio.seek(0)
+        writer = ExcelWriter(bio, engine=engine)
+        df_style = self.df.style
+        df_style.applymap(lambda x: "border: red 1px solid;")
+        df_style.applymap(lambda x: "color: blue")
+        df_style.applymap(lambda x: "border-color: green black", subset=["float1"])
+        df_style.to_excel(writer, sheet_name="Sheet1")
+        writer.save()
+
+
 class ReadExcel:
 
     params = ["xlrd", "openpyxl", "odf"]
diff --git a/doc/source/whatsnew/v1.5.0.rst b/doc/source/whatsnew/v1.5.0.rst
index 6cc0190f00e31..a4fa31f7fc368 100644
--- a/doc/source/whatsnew/v1.5.0.rst
+++ b/doc/source/whatsnew/v1.5.0.rst
@@ -752,6 +752,7 @@ Performance improvements
 - Performance improvement in :func:`factorize` (:issue:`46109`)
 - Performance improvement in :class:`DataFrame` and :class:`Series` constructors for extension dtype scalars (:issue:`45854`)
 - Performance improvement in :func:`read_excel` when ``nrows`` argument provided (:issue:`32727`)
+- Performance improvement in :meth:`.Styler.to_excel` when applying repeated CSS formats (:issue:`47371`)
 - Performance improvement in :meth:`MultiIndex.is_monotonic_increasing`  (:issue:`47458`)
 
 .. ---------------------------------------------------------------------------
diff --git a/pandas/io/formats/css.py b/pandas/io/formats/css.py
index a6d2645590dde..92dafffc9c3de 100644
--- a/pandas/io/formats/css.py
+++ b/pandas/io/formats/css.py
@@ -7,6 +7,7 @@
 from typing import (
     Callable,
     Generator,
+    Iterable,
     Iterator,
 )
 import warnings
@@ -188,9 +189,24 @@ class CSSResolver:
 
     SIDES = ("top", "right", "bottom", "left")
 
+    CSS_EXPANSIONS = {
+        **{
+            "-".join(["border", prop] if prop else ["border"]): _border_expander(prop)
+            for prop in ["", "top", "right", "bottom", "left"]
+        },
+        **{
+            "-".join(["border", prop]): _side_expander("border-{:s}-" + prop)
+            for prop in ["color", "style", "width"]
+        },
+        **{
+            "margin": _side_expander("margin-{:s}"),
+            "padding": _side_expander("padding-{:s}"),
+        },
+    }
+
     def __call__(
         self,
-        declarations_str: str,
+        declarations: str | Iterable[tuple[str, str]],
         inherited: dict[str, str] | None = None,
     ) -> dict[str, str]:
         """
@@ -198,8 +214,10 @@ def __call__(
 
         Parameters
         ----------
-        declarations_str : str
-            A list of CSS declarations
+        declarations_str : str | Iterable[tuple[str, str]]
+            A CSS string or set of CSS declaration tuples
+            e.g. "font-weight: bold; background: blue" or
+            {("font-weight", "bold"), ("background", "blue")}
         inherited : dict, optional
             Atomic properties indicating the inherited style context in which
             declarations_str is to be resolved. ``inherited`` should already
@@ -230,7 +248,9 @@ def __call__(
          ('font-size', '24pt'),
          ('font-weight', 'bold')]
         """
-        props = dict(self.atomize(self.parse(declarations_str)))
+        if isinstance(declarations, str):
+            declarations = self.parse(declarations)
+        props = dict(self.atomize(declarations))
         if inherited is None:
             inherited = {}
 
@@ -347,28 +367,15 @@ def _error():
             size_fmt = f"{val:f}pt"
         return size_fmt
 
-    def atomize(self, declarations) -> Generator[tuple[str, str], None, None]:
+    def atomize(self, declarations: Iterable) -> Generator[tuple[str, str], None, None]:
         for prop, value in declarations:
-            attr = "expand_" + prop.replace("-", "_")
-            try:
-                expand = getattr(self, attr)
-            except AttributeError:
-                yield prop, value
+            prop = prop.lower()
+            value = value.lower()
+            if prop in self.CSS_EXPANSIONS:
+                expand = self.CSS_EXPANSIONS[prop]
+                yield from expand(self, prop, value)
             else:
-                for prop, value in expand(prop, value):
-                    yield prop, value
-
-    expand_border = _border_expander()
-    expand_border_top = _border_expander("top")
-    expand_border_right = _border_expander("right")
-    expand_border_bottom = _border_expander("bottom")
-    expand_border_left = _border_expander("left")
-
-    expand_border_color = _side_expander("border-{:s}-color")
-    expand_border_style = _side_expander("border-{:s}-style")
-    expand_border_width = _side_expander("border-{:s}-width")
-    expand_margin = _side_expander("margin-{:s}")
-    expand_padding = _side_expander("padding-{:s}")
+                yield prop, value
 
     def parse(self, declarations_str: str) -> Iterator[tuple[str, str]]:
         """
diff --git a/pandas/io/formats/excel.py b/pandas/io/formats/excel.py
index 8478b72d97a5e..811b079c3c693 100644
--- a/pandas/io/formats/excel.py
+++ b/pandas/io/formats/excel.py
@@ -3,7 +3,10 @@
 """
 from __future__ import annotations
 
-from functools import reduce
+from functools import (
+    lru_cache,
+    reduce,
+)
 import itertools
 import re
 from typing import (
@@ -85,10 +88,13 @@ def __init__(
         **kwargs,
     ) -> None:
         if css_styles and css_converter:
-            css = ";".join(
-                [a + ":" + str(v) for (a, v) in css_styles[css_row, css_col]]
-            )
-            style = css_converter(css)
+            # Use dict to get only one (case-insensitive) declaration per property
+            declaration_dict = {
+                prop.lower(): val for prop, val in css_styles[css_row, css_col]
+            }
+            # Convert to frozenset for order-invariant caching
+            unique_declarations = frozenset(declaration_dict.items())
+            style = css_converter(unique_declarations)
 
         return super().__init__(row=row, col=col, val=val, style=style, **kwargs)
 
@@ -166,15 +172,19 @@ def __init__(self, inherited: str | None = None) -> None:
 
     compute_css = CSSResolver()
 
-    def __call__(self, declarations_str: str) -> dict[str, dict[str, str]]:
+    @lru_cache(maxsize=None)
+    def __call__(
+        self, declarations: str | frozenset[tuple[str, str]]
+    ) -> dict[str, dict[str, str]]:
         """
         Convert CSS declarations to ExcelWriter style.
 
         Parameters
         ----------
-        declarations_str : str
-            List of CSS declarations.
-            e.g. "font-weight: bold; background: blue"
+        declarations : str | frozenset[tuple[str, str]]
+            CSS string or set of CSS declaration tuples.
+            e.g. "font-weight: bold; background: blue" or
+            {("font-weight", "bold"), ("background", "blue")}
 
         Returns
         -------
@@ -182,8 +192,7 @@ def __call__(self, declarations_str: str) -> dict[str, dict[str, str]]:
             A style as interpreted by ExcelWriter when found in
             ExcelCell.style.
         """
-        # TODO: memoize?
-        properties = self.compute_css(declarations_str, self.inherited)
+        properties = self.compute_css(declarations, self.inherited)
         return self.build_xlstyle(properties)
 
     def build_xlstyle(self, props: Mapping[str, str]) -> dict[str, dict[str, str]]:
diff --git a/pandas/tests/io/formats/test_to_excel.py b/pandas/tests/io/formats/test_to_excel.py
index b95a5b4365f43..b98fd74643207 100644
--- a/pandas/tests/io/formats/test_to_excel.py
+++ b/pandas/tests/io/formats/test_to_excel.py
@@ -11,7 +11,10 @@
 import pandas._testing as tm
 
 from pandas.io.formats.css import CSSWarning
-from pandas.io.formats.excel import CSSToExcelConverter
+from pandas.io.formats.excel import (
+    CssExcelCell,
+    CSSToExcelConverter,
+)
 
 
 @pytest.mark.parametrize(
@@ -340,3 +343,89 @@ def test_css_named_colors_from_mpl_present():
     pd_colors = CSSToExcelConverter.NAMED_COLORS
     for name, color in mpl_colors.items():
         assert name in pd_colors and pd_colors[name] == color[1:]
+
+
+@pytest.mark.parametrize(
+    "styles,expected",
+    [
+        ([("color", "green"), ("color", "red")], "color: red;"),
+        ([("font-weight", "bold"), ("font-weight", "normal")], "font-weight: normal;"),
+        ([("text-align", "center"), ("TEXT-ALIGN", "right")], "text-align: right;"),
+    ],
+)
+def test_css_excel_cell_precedence(styles, expected):
+    """It applies favors latter declarations over former declarations"""
+    # See GH 47371
+    converter = CSSToExcelConverter()
+    converter.__call__.cache_clear()
+    css_styles = {(0, 0): styles}
+    cell = CssExcelCell(
+        row=0,
+        col=0,
+        val="",
+        style=None,
+        css_styles=css_styles,
+        css_row=0,
+        css_col=0,
+        css_converter=converter,
+    )
+    converter.__call__.cache_clear()
+
+    assert cell.style == converter(expected)
+
+
+@pytest.mark.parametrize(
+    "styles,cache_hits,cache_misses",
+    [
+        ([[("color", "green"), ("color", "red"), ("color", "green")]], 0, 1),
+        (
+            [
+                [("font-weight", "bold")],
+                [("font-weight", "normal"), ("font-weight", "bold")],
+            ],
+            1,
+            1,
+        ),
+        ([[("text-align", "center")], [("TEXT-ALIGN", "center")]], 1, 1),
+        (
+            [
+                [("font-weight", "bold"), ("text-align", "center")],
+                [("font-weight", "bold"), ("text-align", "left")],
+            ],
+            0,
+            2,
+        ),
+        (
+            [
+                [("font-weight", "bold"), ("text-align", "center")],
+                [("font-weight", "bold"), ("text-align", "left")],
+                [("font-weight", "bold"), ("text-align", "center")],
+            ],
+            1,
+            2,
+        ),
+    ],
+)
+def test_css_excel_cell_cache(styles, cache_hits, cache_misses):
+    """It caches unique cell styles"""
+    # See GH 47371
+    converter = CSSToExcelConverter()
+    converter.__call__.cache_clear()
+
+    css_styles = {(0, i): _style for i, _style in enumerate(styles)}
+    for css_row, css_col in css_styles:
+        CssExcelCell(
+            row=0,
+            col=0,
+            val="",
+            style=None,
+            css_styles=css_styles,
+            css_row=css_row,
+            css_col=css_col,
+            css_converter=converter,
+        )
+    cache_info = converter.__call__.cache_info()
+    converter.__call__.cache_clear()
+
+    assert cache_info.hits == cache_hits
+    assert cache_info.misses == cache_misses