diff --git a/pandas/core/algorithms.py b/pandas/core/algorithms.py
index 6f906cf8879ff..ed51bb8034419 100644
--- a/pandas/core/algorithms.py
+++ b/pandas/core/algorithms.py
@@ -466,7 +466,7 @@ def isin(comps: AnyArrayLike, values: AnyArrayLike) -> np.ndarray:
         # Avoid raising in extract_array
         values = np.array(values)
     else:
-        values = extract_array(values, extract_numpy=True)
+        values = extract_array(values, extract_numpy=True, extract_range=True)
 
     comps = _ensure_arraylike(comps)
     comps = extract_array(comps, extract_numpy=True)
diff --git a/pandas/tests/indexes/ranges/test_range.py b/pandas/tests/indexes/ranges/test_range.py
index 3d36e03751f95..3f77c2c974842 100644
--- a/pandas/tests/indexes/ranges/test_range.py
+++ b/pandas/tests/indexes/ranges/test_range.py
@@ -524,3 +524,11 @@ def test_append_len_one(self, RI):
         # GH39401
         result = RI.append([])
         tm.assert_index_equal(result, RI, exact=True)
+
+    @pytest.mark.parametrize("base", [RangeIndex(0, 2), Index([0, 1])])
+    def test_isin_range(self, base):
+        # GH#41151
+        values = RangeIndex(0, 1)
+        result = base.isin(values)
+        expected = np.array([True, False])
+        tm.assert_numpy_array_equal(result, expected)