diff --git a/doc/source/whatsnew/v1.2.4.rst b/doc/source/whatsnew/v1.2.4.rst
index c7bc337239faf..45d131327630e 100644
--- a/doc/source/whatsnew/v1.2.4.rst
+++ b/doc/source/whatsnew/v1.2.4.rst
@@ -17,6 +17,7 @@ Fixed regressions
 
 - Fixed regression in :meth:`DataFrame.sum` when ``min_count`` greater than the :class:`DataFrame` shape was passed resulted in a ``ValueError`` (:issue:`39738`)
 - Fixed regression in :meth:`DataFrame.to_json` raising ``AttributeError`` when run on PyPy (:issue:`39837`)
+- Fixed regression in :meth:`DataFrame.where` not returning a copy in the case of an all True condition (:issue:`39595`)
 -
 
 .. ---------------------------------------------------------------------------
diff --git a/pandas/core/internals/blocks.py b/pandas/core/internals/blocks.py
index c13eb3f109354..79cf31c5caaac 100644
--- a/pandas/core/internals/blocks.py
+++ b/pandas/core/internals/blocks.py
@@ -1327,7 +1327,8 @@ def where(self, other, cond, errors="raise") -> List[Block]:
 
         if noop:
             # TODO: avoid the downcasting at the end in this case?
-            result = values
+            # GH-39595: Always return a copy
+            result = values.copy()
         else:
             # see if we can operate on the entire block, or need item-by-item
             # or if we are a single block (ndim == 1)
diff --git a/pandas/tests/frame/indexing/test_where.py b/pandas/tests/frame/indexing/test_where.py
index bc84d7c70b01c..574fa46d10f67 100644
--- a/pandas/tests/frame/indexing/test_where.py
+++ b/pandas/tests/frame/indexing/test_where.py
@@ -692,3 +692,20 @@ def test_where_try_cast_deprecated(frame_or_series):
     with tm.assert_produces_warning(FutureWarning):
         # try_cast keyword deprecated
         obj.where(mask, -1, try_cast=False)
+
+
+def test_where_copies_with_noop(frame_or_series):
+    # GH-39595
+    result = frame_or_series([1, 2, 3, 4])
+    expected = result.copy()
+    col = result[0] if frame_or_series is DataFrame else result
+
+    where_res = result.where(col < 5)
+    where_res *= 2
+
+    tm.assert_equal(result, expected)
+
+    where_res = result.where(col > 5, [1, 2, 3, 4])
+    where_res *= 2
+
+    tm.assert_equal(result, expected)