diff --git a/environment.yml b/environment.yml
index 4622aac1dc6f8..badb0ba94a670 100644
--- a/environment.yml
+++ b/environment.yml
@@ -106,6 +106,7 @@ dependencies:
   - cftime  # Needed for downstream xarray.CFTimeIndex test
   - pyreadstat  # pandas.read_spss
   - tabulate>=0.8.3  # DataFrame.to_markdown
+  - natsort  # DataFrame.sort_values
   - pip:
     - git+https://github.com/pandas-dev/pydata-sphinx-theme.git@master
     - git+https://github.com/numpy/numpydoc
diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index 5336d0828881b..b0e979331209c 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -4406,6 +4406,32 @@ def sort_values(
         3  NaN     8     4    D
         4    D     7     2    e
         5    C     4     3    F
+
+        Natural sort with the key argument,
+        using the `natsort <https://github.com/SethMMorton/natsort>` package.
+
+        >>> df = pd.DataFrame({
+        ...    "time": ['0hr', '128hr', '72hr', '48hr', '96hr'],
+        ...    "value": [10, 20, 30, 40, 50]
+        ... })
+        >>> df
+            time  value
+        0    0hr     10
+        1  128hr     20
+        2   72hr     30
+        3   48hr     40
+        4   96hr     50
+        >>> from natsort import index_natsorted
+        >>> df.sort_values(
+        ...    by="time",
+        ...    key=lambda x: np.argsort(index_natsorted(df["time"]))
+        ... )
+            time  value
+        0    0hr     10
+        3   48hr     40
+        2   72hr     30
+        4   96hr     50
+        1  128hr     20
         """
         raise AbstractMethodError(self)
 
diff --git a/requirements-dev.txt b/requirements-dev.txt
index cc3775de3a4ba..c53ced35d27fa 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -73,6 +73,7 @@ xarray
 cftime
 pyreadstat
 tabulate>=0.8.3
+natsort
 git+https://github.com/pandas-dev/pydata-sphinx-theme.git@master
 git+https://github.com/numpy/numpydoc
 pyflakes>=2.2.0
\ No newline at end of file