diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index da152b70abd2e..8cad92ab2bb32 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -8569,6 +8569,14 @@ def isin(self, values) -> "DataFrame":
 
     # ----------------------------------------------------------------------
     # Add index and columns
+    _AXIS_ORDERS = ["index", "columns"]
+    _AXIS_NUMBERS = {"index": 0, "columns": 1}
+    _AXIS_NAMES = {0: "index", 1: "columns"}
+    _AXIS_REVERSED = True
+    _AXIS_LEN = len(_AXIS_ORDERS)
+    _info_axis_number = 1
+    _info_axis_name = "columns"
+
     index: "Index" = properties.AxisProperty(
         axis=1, doc="The index (row labels) of the DataFrame."
     )
@@ -8584,13 +8592,6 @@ def isin(self, values) -> "DataFrame":
     sparse = CachedAccessor("sparse", SparseFrameAccessor)
 
 
-DataFrame._setup_axes(
-    ["index", "columns"],
-    docs={
-        "index": "The index (row labels) of the DataFrame.",
-        "columns": "The column labels of the DataFrame.",
-    },
-)
 DataFrame._add_numeric_operations()
 DataFrame._add_series_or_dataframe_operations()
 
diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index 934c4c6e92bbe..60d152eba4485 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -315,28 +315,6 @@ def _constructor_expanddim(self):
     _info_axis_name: str
     _AXIS_LEN: int
 
-    @classmethod
-    def _setup_axes(cls, axes: List[str], docs: Dict[str, str]) -> None:
-        """
-        Provide axes setup for the major PandasObjects.
-
-        Parameters
-        ----------
-        axes : the names of the axes in order (lowest to highest)
-        docs : docstrings for the axis properties
-        """
-        info_axis = len(axes) - 1
-        axes_are_reversed = len(axes) > 1
-
-        cls._AXIS_ORDERS = axes
-        cls._AXIS_NUMBERS = {a: i for i, a in enumerate(axes)}
-        cls._AXIS_LEN = len(axes)
-        cls._AXIS_NAMES = dict(enumerate(axes))
-        cls._AXIS_REVERSED = axes_are_reversed
-
-        cls._info_axis_number = info_axis
-        cls._info_axis_name = axes[info_axis]
-
     def _construct_axes_dict(self, axes=None, **kwargs):
         """Return an axes dictionary for myself."""
         d = {a: self._get_axis(a) for a in (axes or self._AXIS_ORDERS)}
diff --git a/pandas/core/series.py b/pandas/core/series.py
index 24e794014a15f..f6536884e007a 100644
--- a/pandas/core/series.py
+++ b/pandas/core/series.py
@@ -4562,6 +4562,14 @@ def to_period(self, freq=None, copy=True) -> "Series":
 
     # ----------------------------------------------------------------------
     # Add index
+    _AXIS_ORDERS = ["index"]
+    _AXIS_NUMBERS = {"index": 0}
+    _AXIS_NAMES = {0: "index"}
+    _AXIS_REVERSED = False
+    _AXIS_LEN = len(_AXIS_ORDERS)
+    _info_axis_number = 0
+    _info_axis_name = "index"
+
     index: "Index" = properties.AxisProperty(
         axis=0, doc="The index (axis labels) of the Series."
     )
@@ -4580,7 +4588,6 @@ def to_period(self, freq=None, copy=True) -> "Series":
     hist = pandas.plotting.hist_series
 
 
-Series._setup_axes(["index"], docs={"index": "The index (axis labels) of the Series."})
 Series._add_numeric_operations()
 Series._add_series_or_dataframe_operations()