diff --git a/pandas/_config/config.py b/pandas/_config/config.py
index 8f75d0381c1a6..9e74eb46f7b1f 100644
--- a/pandas/_config/config.py
+++ b/pandas/_config/config.py
@@ -462,6 +462,7 @@ def register_option(key: str, defval: object, doc="", validator=None, cb=None):
 
     cursor = _global_config
     msg = "Path prefix to option '{option}' is already an option"
+
     for i, p in enumerate(path[:-1]):
         if not isinstance(cursor, dict):
             raise OptionError(msg.format(option=".".join(path[:i])))
@@ -650,8 +651,9 @@ def _build_option_description(k):
         s += f"\n    [default: {o.defval}] [currently: {_get_option(k, True)}]"
 
     if d:
+        rkey = d.rkey if d.rkey else ""
         s += "\n    (Deprecated"
-        s += ", use `{rkey}` instead.".format(rkey=d.rkey if d.rkey else "")
+        s += f", use `{rkey}` instead."
         s += ")"
 
     return s
diff --git a/pandas/_config/localization.py b/pandas/_config/localization.py
index ba60b1e003004..dd1d4948aa6e3 100644
--- a/pandas/_config/localization.py
+++ b/pandas/_config/localization.py
@@ -161,6 +161,6 @@ def get_locales(prefix=None, normalize=True, locale_getter=_default_locale_gette
     if prefix is None:
         return _valid_locales(out_locales, normalize)
 
-    pattern = re.compile("{prefix}.*".format(prefix=prefix))
+    pattern = re.compile(f"{prefix}.*")
     found = pattern.findall("\n".join(out_locales))
     return _valid_locales(found, normalize)
diff --git a/setup.py b/setup.py
index e42a570200dc3..38fc57e4f80bf 100755
--- a/setup.py
+++ b/setup.py
@@ -39,9 +39,9 @@ def is_platform_mac():
     "install_requires": [
         "python-dateutil >= 2.6.1",
         "pytz >= 2017.2",
-        "numpy >= {numpy_ver}".format(numpy_ver=min_numpy_ver),
+        f"numpy >= {min_numpy_ver}",
     ],
-    "setup_requires": ["numpy >= {numpy_ver}".format(numpy_ver=min_numpy_ver)],
+    "setup_requires": [f"numpy >= {min_numpy_ver}"],
     "zip_safe": False,
 }
 
@@ -364,10 +364,8 @@ def run(self):
                 for pyxfile in pyxfiles:
                     sourcefile = pyxfile[:-3] + extension
                     msg = (
-                        "{extension}-source file '{source}' not found.\n"
-                        "Run 'setup.py cython' before sdist.".format(
-                            source=sourcefile, extension=extension
-                        )
+                        f"{extension}-source file '{sourcefile}' not found.\n"
+                        f"Run 'setup.py cython' before sdist."
                     )
                     assert os.path.isfile(sourcefile), msg
         sdist_class.run(self)
@@ -382,14 +380,12 @@ def check_cython_extensions(self, extensions):
         for ext in extensions:
             for src in ext.sources:
                 if not os.path.exists(src):
-                    print("{}: -> [{}]".format(ext.name, ext.sources))
+                    print(f"{ext.name}: -> [{ext.sources}]")
                     raise Exception(
-                        """Cython-generated file '{src}' not found.
+                        f"""Cython-generated file '{src}' not found.
                 Cython is required to compile pandas from a development branch.
                 Please install Cython or download a release package of pandas.
-                """.format(
-                            src=src
-                        )
+                """
                     )
 
     def build_extensions(self):
@@ -706,7 +702,7 @@ def srcpath(name=None, suffix=".pyx", subdir="src"):
     include = data.get("include")
 
     obj = Extension(
-        "pandas.{name}".format(name=name),
+        f"pandas.{name}",
         sources=sources,
         depends=data.get("depends", []),
         include_dirs=include,