diff --git a/pandas/_libs/internals.pyx b/pandas/_libs/internals.pyx
index 8e61a772912af..ba108c4524b9c 100644
--- a/pandas/_libs/internals.pyx
+++ b/pandas/_libs/internals.pyx
@@ -1,7 +1,7 @@
 import cython
 from cython import Py_ssize_t
 
-from cpython.object cimport PyObject
+from cpython.slice cimport PySlice_GetIndicesEx
 
 cdef extern from "Python.h":
     Py_ssize_t PY_SSIZE_T_MAX
@@ -9,13 +9,6 @@ cdef extern from "Python.h":
 import numpy as np
 from numpy cimport int64_t
 
-cdef extern from "compat_helper.h":
-    cdef int slice_get_indices(PyObject* s, Py_ssize_t length,
-                               Py_ssize_t *start, Py_ssize_t *stop,
-                               Py_ssize_t *step,
-                               Py_ssize_t *slicelength) except -1
-
-
 from pandas._libs.algos import ensure_int64
 
 
@@ -258,8 +251,8 @@ cpdef Py_ssize_t slice_len(
     if slc is None:
         raise TypeError("slc must be slice")
 
-    slice_get_indices(<PyObject *>slc, objlen,
-                      &start, &stop, &step, &length)
+    PySlice_GetIndicesEx(slc, objlen,
+                         &start, &stop, &step, &length)
 
     return length
 
@@ -278,8 +271,8 @@ cdef slice_get_indices_ex(slice slc, Py_ssize_t objlen=PY_SSIZE_T_MAX):
     if slc is None:
         raise TypeError("slc should be a slice")
 
-    slice_get_indices(<PyObject *>slc, objlen,
-                      &start, &stop, &step, &length)
+    PySlice_GetIndicesEx(slc, objlen,
+                         &start, &stop, &step, &length)
 
     return start, stop, step, length
 
diff --git a/pandas/_libs/src/compat_helper.h b/pandas/_libs/src/compat_helper.h
deleted file mode 100644
index 01d5b843d1bb6..0000000000000
--- a/pandas/_libs/src/compat_helper.h
+++ /dev/null
@@ -1,45 +0,0 @@
-/*
-Copyright (c) 2016, PyData Development Team
-All rights reserved.
-
-Distributed under the terms of the BSD Simplified License.
-
-The full license is in the LICENSE file, distributed with this software.
-*/
-
-#ifndef PANDAS__LIBS_SRC_COMPAT_HELPER_H_
-#define PANDAS__LIBS_SRC_COMPAT_HELPER_H_
-
-#include "Python.h"
-#include "inline_helper.h"
-
-/*
-PySlice_GetIndicesEx changes signature in PY3
-but 3.6.1 in particular changes the behavior of this function slightly
-https://bugs.python.org/issue27867
-
-
-In 3.6.1 PySlice_GetIndicesEx was changed to a macro
-inadvertently breaking ABI compat.  For now, undefing
-the macro, which restores compat.
-https://github.com/pandas-dev/pandas/issues/15961
-https://bugs.python.org/issue29943
-*/
-
-#ifndef PYPY_VERSION
-# if PY_VERSION_HEX < 0x03070000 && defined(PySlice_GetIndicesEx)
-#   undef PySlice_GetIndicesEx
-# endif  // PY_VERSION_HEX
-#endif  // PYPY_VERSION
-
-PANDAS_INLINE int slice_get_indices(PyObject *s,
-                                    Py_ssize_t length,
-                                    Py_ssize_t *start,
-                                    Py_ssize_t *stop,
-                                    Py_ssize_t *step,
-                                    Py_ssize_t *slicelength) {
-  return PySlice_GetIndicesEx(s, length, start, stop,
-                              step, slicelength);
-}
-
-#endif  // PANDAS__LIBS_SRC_COMPAT_HELPER_H_
diff --git a/setup.py b/setup.py
index a7bc7a333cdd6..545765ecb114d 100755
--- a/setup.py
+++ b/setup.py
@@ -83,10 +83,7 @@ def is_platform_mac():
 
 
 _pxi_dep_template = {
-    "algos": [
-        "_libs/algos_common_helper.pxi.in",
-        "_libs/algos_take_helper.pxi.in",
-    ],
+    "algos": ["_libs/algos_common_helper.pxi.in", "_libs/algos_take_helper.pxi.in"],
     "hashtable": [
         "_libs/hashtable_class_helper.pxi.in",
         "_libs/hashtable_func_helper.pxi.in",
@@ -544,7 +541,7 @@ def srcpath(name=None, suffix=".pyx", subdir="src"):
 ts_include = ["pandas/_libs/tslibs/src", "pandas/_libs/tslibs"]
 
 
-lib_depends = ["pandas/_libs/src/parse_helper.h", "pandas/_libs/src/compat_helper.h"]
+lib_depends = ["pandas/_libs/src/parse_helper.h"]
 
 np_datetime_headers = [
     "pandas/_libs/tslibs/src/datetime/np_datetime.h",
@@ -823,5 +820,5 @@ def srcpath(name=None, suffix=".pyx", subdir="src"):
     entry_points={
         "pandas_plotting_backends": ["matplotlib = pandas:plotting._matplotlib"]
     },
-    **setuptools_kwargs
+    **setuptools_kwargs,
 )