diff --git a/doc/source/whatsnew/v0.17.0.txt b/doc/source/whatsnew/v0.17.0.txt
index 9293c6b36879b..e021eb9d02abe 100644
--- a/doc/source/whatsnew/v0.17.0.txt
+++ b/doc/source/whatsnew/v0.17.0.txt
@@ -75,3 +75,4 @@ Bug Fixes
 - Bug in ``DataFrame.reset_index`` when index contains `NaT`. (:issue:`10388`)
 - Bug in ``ExcelReader`` when worksheet is empty (:issue:`6403`)
 - Bug in ``Table.select_column`` where name is not preserved (:issue:`10392`)
+- Bug in ``DataFrame.interpolate`` with ``axis=1`` and ``inplace=True`` (:issue:`10395`)
diff --git a/pandas/core/generic.py b/pandas/core/generic.py
index 35db4051c60c8..b9e007a1e4d58 100644
--- a/pandas/core/generic.py
+++ b/pandas/core/generic.py
@@ -2925,47 +2925,50 @@ def interpolate(self, method='linear', axis=0, limit=None, inplace=False,
 
         if axis == 0:
             ax = self._info_axis_name
+            _maybe_transposed_self = self
         elif axis == 1:
-            self = self.T
+            _maybe_transposed_self = self.T
             ax = 1
-        ax = self._get_axis_number(ax)
+        else:
+            _maybe_transposed_self = self
+        ax = _maybe_transposed_self._get_axis_number(ax)
 
-        if self.ndim == 2:
+        if _maybe_transposed_self.ndim == 2:
             alt_ax = 1 - ax
         else:
             alt_ax = ax
 
-        if isinstance(self.index, MultiIndex) and method != 'linear':
+        if isinstance(_maybe_transposed_self.index, MultiIndex) and method != 'linear':
             raise ValueError("Only `method=linear` interpolation is supported "
                              "on MultiIndexes.")
 
-        if self._data.get_dtype_counts().get('object') == len(self.T):
+        if _maybe_transposed_self._data.get_dtype_counts().get('object') == len(_maybe_transposed_self.T):
             raise TypeError("Cannot interpolate with all NaNs.")
 
         # create/use the index
         if method == 'linear':
-            index = np.arange(len(self._get_axis(alt_ax)))  # prior default
+            index = np.arange(len(_maybe_transposed_self._get_axis(alt_ax)))  # prior default
         else:
-            index = self._get_axis(alt_ax)
+            index = _maybe_transposed_self._get_axis(alt_ax)
 
         if pd.isnull(index).any():
             raise NotImplementedError("Interpolation with NaNs in the index "
                                       "has not been implemented. Try filling "
                                       "those NaNs before interpolating.")
-        new_data = self._data.interpolate(method=method,
-                                          axis=ax,
-                                          index=index,
-                                          values=self,
-                                          limit=limit,
-                                          inplace=inplace,
-                                          downcast=downcast,
-                                          **kwargs)
+        new_data = _maybe_transposed_self._data.interpolate(
+            method=method,
+            axis=ax,
+            index=index,
+            values=_maybe_transposed_self,
+            limit=limit,
+            inplace=inplace,
+            downcast=downcast,
+            **kwargs
+        )
         if inplace:
             if axis == 1:
-                self._update_inplace(new_data)
-                self = self.T
-            else:
-                self._update_inplace(new_data)
+                new_data = self._constructor(new_data).T._data
+            self._update_inplace(new_data)
         else:
             res = self._constructor(new_data).__finalize__(self)
             if axis == 1:
diff --git a/pandas/tests/test_generic.py b/pandas/tests/test_generic.py
index 44f7791b7f8ba..9a8ec00188d9c 100644
--- a/pandas/tests/test_generic.py
+++ b/pandas/tests/test_generic.py
@@ -1117,6 +1117,14 @@ def test_interp_inplace(self):
         result['a'].interpolate(inplace=True, downcast='infer')
         assert_frame_equal(result, expected.astype('int64'))
 
+    def test_interp_inplace_row(self):
+        # GH 10395
+        result = DataFrame({'a': [1.,2.,3.,4.], 'b': [np.nan, 2., 3., 4.],
+                            'c': [3, 2, 2, 2]})
+        expected = result.interpolate(method='linear', axis=1, inplace=False)
+        result.interpolate(method='linear', axis=1, inplace=True)
+        assert_frame_equal(result, expected)
+
     def test_interp_ignore_all_good(self):
         # GH
         df = DataFrame({'A': [1, 2, np.nan, 4],