diff --git a/pandas-stubs/core/indexing.pyi b/pandas-stubs/core/indexing.pyi
index 938696292..90374106b 100644
--- a/pandas-stubs/core/indexing.pyi
+++ b/pandas-stubs/core/indexing.pyi
@@ -1,5 +1,4 @@
 from typing import (
-    Generic,
     TypeVar,
     Union,
 )
@@ -9,14 +8,19 @@ from pandas.core.indexes.api import Index
 
 from pandas._libs.indexing import _NDFrameIndexerBase
 from pandas._typing import (
+    MaskType,
     Scalar,
-    StrLike,
+    ScalarT,
 )
 
-_IndexSliceT = TypeVar("_IndexSliceT", bound=Union[StrLike, Scalar, slice])
+_IndexSliceTuple = Union[
+    slice, tuple[Union[Index, MaskType, Scalar, list[ScalarT], slice], ...]
+]
 
-class _IndexSlice(Generic[_IndexSliceT]):
-    def __getitem__(self, arg) -> tuple[_IndexSliceT, ...]: ...
+_IndexSliceTupleT = TypeVar("_IndexSliceTupleT", bound=_IndexSliceTuple)
+
+class _IndexSlice:
+    def __getitem__(self, arg: _IndexSliceTupleT) -> _IndexSliceTupleT: ...
 
 IndexSlice: _IndexSlice
 
diff --git a/tests/test_frame.py b/tests/test_frame.py
index c1e66c3fe..d4c4f2f6c 100644
--- a/tests/test_frame.py
+++ b/tests/test_frame.py
@@ -1278,6 +1278,28 @@ def test_indexslice_setitem():
     df.loc[pd.IndexSlice[2, :], "z"] = [200, 300]
 
 
+def test_indexslice_getitem():
+    # GH 300
+    df = (
+        pd.DataFrame({"x": [1, 2, 2, 3, 4], "y": [10, 20, 30, 40, 10]})
+        .assign(z=lambda df: df.x * df.y)
+        .set_index(["x", "y"])
+    )
+    ind = pd.Index([2, 3])
+    check(assert_type(pd.IndexSlice[ind, :], "tuple[pd.Index, slice]"), tuple)
+    check(assert_type(df.loc[pd.IndexSlice[ind, :]], pd.DataFrame), pd.DataFrame)
+    check(assert_type(df.loc[pd.IndexSlice[1:2]], pd.DataFrame), pd.DataFrame)
+    check(
+        assert_type(df.loc[pd.IndexSlice[:, df["z"] > 40], :], pd.DataFrame),
+        pd.DataFrame,
+    )
+    check(assert_type(df.loc[pd.IndexSlice[2, 30], "z"], Scalar), np.int64)
+    check(
+        assert_type(df.loc[pd.IndexSlice[[2, 4], [20, 40]], :], pd.DataFrame),
+        pd.DataFrame,
+    )
+
+
 def test_compute_values():
     df = pd.DataFrame({"x": [1, 2, 3, 4]})
     s: pd.Series = pd.Series([10, 20, 30, 40])