diff --git a/.gitignore b/.gitignore
index 147e7e1e..33e26ed4 100644
--- a/.gitignore
+++ b/.gitignore
@@ -68,6 +68,7 @@ dist
 **/wheelhouse/*
 # coverage
 .coverage
+.nox
 
 # OS generated files #
 ######################
diff --git a/.travis.yml b/.travis.yml
index 42378680..bce116d2 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -3,48 +3,50 @@ sudo: false
 language: python
 
 env:
-  - PYTHON=2.7 PANDAS=0.19.2 COVERAGE='false' LINT='true'
-  - PYTHON=3.5 PANDAS=0.18.1 COVERAGE='true' LINT='false'
-  - PYTHON=3.6 PANDAS=0.20.1 COVERAGE='false' LINT='false'
-  - PYTHON=3.6 PANDAS=MASTER COVERAGE='false' LINT='true'
+  - PYTHON=2.7 PANDAS=0.19.2 COVERAGE='false' LINT='true' PYENV_VERSION=2.7.14
+  - PYTHON=3.5 PANDAS=0.18.1 COVERAGE='true' LINT='false' PYENV_VERSION=3.5.4
+  - PYTHON=3.6 PANDAS=0.20.1 COVERAGE='false' LINT='false' PYENV_VERSION=3.6.1
+  - PYTHON=3.6 PANDAS=MASTER COVERAGE='false' LINT='true' PYENV_VERSION=3.6.1
 
 before_install:
   - echo "before_install"
   - source ci/travis_process_gbq_encryption.sh
 
 install:
-  - wget http://repo.continuum.io/miniconda/Miniconda3-latest-Linux-x86_64.sh -O miniconda.sh;
-  - bash miniconda.sh -b -p $HOME/miniconda
-  - export PATH="$HOME/miniconda/bin:$PATH"
-  - hash -r
-  - conda config --set always_yes yes --set changeps1 no
-  - conda config --add channels pandas
-  - conda config --add channels conda-forge
-  - conda update -q conda
-  - conda info -a
-  - conda create -q -n test-environment python=$PYTHON
-  - source activate test-environment
-  - if [[ "$PANDAS" == "MASTER" ]]; then
-      conda install -q numpy pytz python-dateutil;
-      PRE_WHEELS="https://7933911d6844c6c53a7d-47bd50c35cd79bd838daf386af554a83.ssl.cf2.rackcdn.com";
-      pip install --pre --upgrade --timeout=60 -f $PRE_WHEELS pandas;
-      pip install -e 'git+https://github.com/GoogleCloudPlatform/google-cloud-python.git#egg=version_subpkg&subdirectory=api_core';
-      pip install -e 'git+https://github.com/GoogleCloudPlatform/google-cloud-python.git#egg=version_subpkg&subdirectory=core';
-      pip install -e 'git+https://github.com/GoogleCloudPlatform/google-cloud-python.git#egg=version_subpkg&subdirectory=bigquery';
+  # work around https://github.com/travis-ci/travis-ci/issues/8363
+  # https://github.com/pre-commit/pre-commit/commit/e3ab8902692e896da9ded42bd4d76ea4e1de359d
+  - pyenv install -s $PYENV_VERSION
+  - pyenv global system $PYENV_VERSION
+  - REQ="ci/requirements-${PYTHON}-${PANDAS}" ;
+    if [ -f "$REQ.pip" ]; then
+      pip install --upgrade nox-automation ;
     else
+      wget http://repo.continuum.io/miniconda/Miniconda3-latest-Linux-x86_64.sh -O miniconda.sh;
+      bash miniconda.sh -b -p $HOME/miniconda ;
+      export PATH="$HOME/miniconda/bin:$PATH" ;
+      hash -r ;
+      conda config --set always_yes yes --set changeps1 no ;
+      conda config --add channels pandas ;
+      conda config --add channels conda-forge ;
+      conda update -q conda ;
+      conda info -a ;
+      conda create -q -n test-environment python=$PYTHON ;
+      source activate test-environment ;
       conda install -q pandas=$PANDAS;
-    fi
-  - pip install coverage pytest pytest-cov flake8 codecov
-  - REQ="ci/requirements-${PYTHON}-${PANDAS}"
-  - if [ -f "$REQ.pip" ]; then
-      pip install -r "$REQ.pip";
-    else
+      pip install coverage pytest pytest-cov flake8 codecov ;
       conda install -q --file "$REQ.conda";
+      conda list ;
+      python setup.py install ;
     fi
-  - conda list
-  - python setup.py install
 
 script:
-  - pytest -v --cov=pandas_gbq --cov-report xml:/tmp/pytest-cov.xml pandas_gbq
-  - if [[ $COVERAGE == 'true' ]]; then codecov ; fi
-  - if [[ $LINT == 'true' ]]; then flake8 pandas_gbq -v ; fi
+  - if [[ $PYTHON == '2.7' ]]; then nox -s test27 ; fi
+  - if [[ $PYTHON == '3.5' ]]; then nox -s test35 ; fi
+  - if [[ $PYTHON == '3.6' ]] && [[ "$PANDAS" == "MASTER" ]]; then nox -s test36master ; fi
+  - REQ="ci/requirements-${PYTHON}-${PANDAS}" ;
+    if [ -f "$REQ.conda" ]; then
+      pip install coverage pytest pytest-cov codecov ;
+      pytest -v --cov=pandas_gbq --cov-report xml:/tmp/pytest-cov.xml pandas_gbq ;
+    fi
+  - if [[ $COVERAGE == 'true' ]]; then nox -s cover ; fi
+  - if [[ $LINT == 'true' ]]; then nox -s lint ; fi
diff --git a/ci/requirements-3.5-0.18.1.pip b/ci/requirements-3.5-0.18.1.pip
index 68ac370d..dd33895c 100644
--- a/ci/requirements-3.5-0.18.1.pip
+++ b/ci/requirements-3.5-0.18.1.pip
@@ -1,4 +1,3 @@
 google-auth==1.4.1
 google-auth-oauthlib==0.0.1
-mock
 google-cloud-bigquery==0.29.0
diff --git a/ci/requirements-3.6-0.20.1.conda b/ci/requirements-3.6-0.20.1.conda
index b52f2aeb..e51ca487 100644
--- a/ci/requirements-3.6-0.20.1.conda
+++ b/ci/requirements-3.6-0.20.1.conda
@@ -1,4 +1,3 @@
 google-auth
 google-auth-oauthlib
-mock
 google-cloud-bigquery
diff --git a/ci/requirements-3.6-MASTER.pip b/ci/requirements-3.6-MASTER.pip
index 78f6834f..bd379b8b 100644
--- a/ci/requirements-3.6-MASTER.pip
+++ b/ci/requirements-3.6-MASTER.pip
@@ -1,3 +1,5 @@
 google-auth
 google-auth-oauthlib
-mock
+git+https://github.com/GoogleCloudPlatform/google-cloud-python.git#egg=version_subpkg&subdirectory=api_core
+git+https://github.com/GoogleCloudPlatform/google-cloud-python.git#egg=version_subpkg&subdirectory=core
+git+https://github.com/GoogleCloudPlatform/google-cloud-python.git#egg=version_subpkg&subdirectory=bigquery
diff --git a/docs/source/changelog.rst b/docs/source/changelog.rst
index ffa62f1a..f7711442 100644
--- a/docs/source/changelog.rst
+++ b/docs/source/changelog.rst
@@ -1,6 +1,11 @@
 Changelog
 =========
 
+0.5.0 / TBD
+-----------
+
+- Tests now use `nox` to run in multiple Python environments. (:issue:`52`)
+
 0.4.1 / 2018-04-05
 ------------------
 
diff --git a/docs/source/contributing.rst b/docs/source/contributing.rst
index 986e61ed..e6467eab 100644
--- a/docs/source/contributing.rst
+++ b/docs/source/contributing.rst
@@ -268,6 +268,19 @@ Or with one of the following constructs::
 
 For more, see the `pytest <http://doc.pytest.org/en/latest/>`_ documentation.
 
+Testing on multiple Python versions
+~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
+
+pandas-gbq uses `nox <https://nox.readthedocs.io>`__ to automate testing in
+multiple Python environments. First, install nox.
+
+.. code-block:: shell
+
+    $ pip install --upgrade nox-automation
+
+To run tests in all versions of Python, run `nox` from the repository's root
+directory.
+
 .. _contributing.gbq_integration_tests:
 
 Running Google BigQuery Integration Tests
diff --git a/nox.py b/nox.py
new file mode 100644
index 00000000..4de95fe9
--- /dev/null
+++ b/nox.py
@@ -0,0 +1,81 @@
+"""Nox test automation configuration.
+
+See: https://nox.readthedocs.io/en/latest/
+"""
+
+import os.path
+
+import nox
+
+
+PANDAS_PRE_WHEELS = (
+    'https://7933911d6844c6c53a7d-47bd50c35cd79bd838daf386af554a83'
+    '.ssl.cf2.rackcdn.com')
+
+
+@nox.session
+def default(session):
+    session.install('mock', 'pytest', 'pytest-cov')
+    session.install('-e', '.')
+    session.run(
+        'pytest',
+        os.path.join('pandas_gbq', 'tests'),
+        '--quiet',
+        '--cov=pandas_gbq',
+        '--cov-report',
+        'xml:/tmp/pytest-cov.xml',
+        *session.posargs
+    )
+
+
+@nox.session
+def test27(session):
+    session.interpreter = 'python2.7'
+    session.install(
+        '-r', os.path.join('.', 'ci', 'requirements-2.7-0.19.2.pip'))
+    default(session)
+
+
+@nox.session
+def test35(session):
+    session.interpreter = 'python3.5'
+    session.install(
+        '-r', os.path.join('.', 'ci', 'requirements-3.5-0.18.1.pip'))
+    default(session)
+
+
+@nox.session
+def test36(session):
+    session.interpreter = 'python3.6'
+    session.install(
+        '-r', os.path.join('.', 'ci', 'requirements-3.6-0.20.1.conda'))
+    default(session)
+
+
+@nox.session
+def test36master(session):
+    session.interpreter = 'python3.6'
+    session.install(
+        '--pre',
+        '--upgrade',
+        '--timeout=60',
+        '-f', PANDAS_PRE_WHEELS,
+        'pandas')
+    session.install(
+        '-r', os.path.join('.', 'ci', 'requirements-3.6-MASTER.pip'))
+    default(session)
+
+
+@nox.session
+def lint(session):
+    session.install('flake8')
+    session.run('flake8', 'pandas_gbq', '-v')
+
+
+@nox.session
+def cover(session):
+    session.interpreter = 'python3.5'
+
+    session.install('coverage', 'pytest-cov')
+    session.run('coverage', 'report', '--show-missing', '--fail-under=40')
+    session.run('coverage', 'erase')
diff --git a/pandas_gbq/tests/test__query.py b/pandas_gbq/tests/test__query.py
index 43ab00f3..09260636 100644
--- a/pandas_gbq/tests/test__query.py
+++ b/pandas_gbq/tests/test__query.py
@@ -1,7 +1,10 @@
 
 import pkg_resources
 
-import mock
+try:
+    import mock
+except ImportError:
+    from unittest import mock
 
 
 @mock.patch('google.cloud.bigquery.QueryJobConfig')
diff --git a/requirements-dev.txt b/requirements-dev.txt
new file mode 100644
index 00000000..e0e72d7f
--- /dev/null
+++ b/requirements-dev.txt
@@ -0,0 +1,6 @@
+flake8
+google-cloud-bigquery
+nox-automation
+pandas
+pytest
+setuptools