diff --git a/bigframes/core/indexers.py b/bigframes/core/indexers.py
index d1a0c42e97..6258eb00d5 100644
--- a/bigframes/core/indexers.py
+++ b/bigframes/core/indexers.py
@@ -27,6 +27,7 @@
 import bigframes.core.guid as guid
 import bigframes.core.indexes as indexes
 import bigframes.core.scalar
+import bigframes.core.window_spec as windows
 import bigframes.dataframe
 import bigframes.dtypes
 import bigframes.exceptions as bfe
@@ -477,6 +478,19 @@ def _iloc_getitem_series_or_dataframe(
                 Union[bigframes.dataframe.DataFrame, bigframes.series.Series],
                 series_or_dataframe.iloc[0:0],
             )
+
+        # Check if both positive index and negative index are necessary
+        if isinstance(key, (bigframes.series.Series, indexes.Index)):
+            # Avoid data download
+            is_key_unisigned = False
+        else:
+            first_sign = key[0] >= 0
+            is_key_unisigned = True
+            for k in key:
+                if (k >= 0) != first_sign:
+                    is_key_unisigned = False
+                    break
+
         if isinstance(series_or_dataframe, bigframes.series.Series):
             original_series_name = series_or_dataframe.name
             series_name = (
@@ -497,7 +511,27 @@ def _iloc_getitem_series_or_dataframe(
         block = df._block
         # explicitly set index to offsets, reset_index may not generate offsets in some modes
         block, offsets_id = block.promote_offsets("temp_iloc_offsets_")
-        block = block.set_index([offsets_id])
+        pos_block = block.set_index([offsets_id])
+
+        if not is_key_unisigned or key[0] < 0:
+            neg_block, size_col_id = block.apply_window_op(
+                offsets_id,
+                ops.aggregations.SizeUnaryOp(),
+                window_spec=windows.rows(),
+            )
+            neg_block, neg_index_id = neg_block.apply_binary_op(
+                offsets_id, size_col_id, ops.SubOp()
+            )
+
+            neg_block = neg_block.set_index([neg_index_id]).drop_columns(
+                [size_col_id, offsets_id]
+            )
+
+        if is_key_unisigned:
+            block = pos_block if key[0] >= 0 else neg_block
+        else:
+            block = pos_block.concat([neg_block], how="inner")
+
         df = bigframes.dataframe.DataFrame(block)
 
         result = df.loc[key]
diff --git a/tests/system/small/test_dataframe.py b/tests/system/small/test_dataframe.py
index b97846d992..c2e4a1c8ad 100644
--- a/tests/system/small/test_dataframe.py
+++ b/tests/system/small/test_dataframe.py
@@ -4400,9 +4400,15 @@ def test_loc_list_multiindex(scalars_dfs_maybe_ordered):
     )
 
 
-def test_iloc_list(scalars_df_index, scalars_pandas_df_index):
-    index_list = [0, 0, 0, 5, 4, 7]
-
+@pytest.mark.parametrize(
+    "index_list",
+    [
+        [0, 1, 2, 3, 4, 4],
+        [0, 0, 0, 5, 4, 7, -2, -5, 3],
+        [-1, -2, -3, -4, -5, -5],
+    ],
+)
+def test_iloc_list(scalars_df_index, scalars_pandas_df_index, index_list):
     bf_result = scalars_df_index.iloc[index_list]
     pd_result = scalars_pandas_df_index.iloc[index_list]
 
@@ -4412,11 +4418,17 @@ def test_iloc_list(scalars_df_index, scalars_pandas_df_index):
     )
 
 
+@pytest.mark.parametrize(
+    "index_list",
+    [
+        [0, 1, 2, 3, 4, 4],
+        [0, 0, 0, 5, 4, 7, -2, -5, 3],
+        [-1, -2, -3, -4, -5, -5],
+    ],
+)
 def test_iloc_list_partial_ordering(
-    scalars_df_partial_ordering, scalars_pandas_df_index
+    scalars_df_partial_ordering, scalars_pandas_df_index, index_list
 ):
-    index_list = [0, 0, 0, 5, 4, 7]
-
     bf_result = scalars_df_partial_ordering.iloc[index_list]
     pd_result = scalars_pandas_df_index.iloc[index_list]