diff --git a/dev-packages/node-integration-tests/suites/express/span-isolationScope/server.ts b/dev-packages/node-integration-tests/suites/express/span-isolationScope/server.ts
new file mode 100644
index 000000000000..99a9c53e932e
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/express/span-isolationScope/server.ts
@@ -0,0 +1,29 @@
+import { loggingTransport } from '@sentry-internal/node-integration-tests';
+import * as Sentry from '@sentry/node';
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  tracesSampleRate: 1.0,
+  transport: loggingTransport,
+});
+
+import { startExpressServerAndSendPortToRunner } from '@sentry-internal/node-integration-tests';
+import express from 'express';
+
+const app = express();
+
+Sentry.setTag('global', 'tag');
+
+app.get('/test/isolationScope', (_req, res) => {
+  // eslint-disable-next-line no-console
+  console.log('This is a test log.');
+  Sentry.addBreadcrumb({ message: 'manual breadcrumb' });
+  Sentry.setTag('isolation-scope', 'tag');
+
+  res.send({});
+});
+
+Sentry.setupExpressErrorHandler(app);
+
+startExpressServerAndSendPortToRunner(app);
diff --git a/dev-packages/node-integration-tests/suites/express/span-isolationScope/test.ts b/dev-packages/node-integration-tests/suites/express/span-isolationScope/test.ts
new file mode 100644
index 000000000000..b6954e426a1d
--- /dev/null
+++ b/dev-packages/node-integration-tests/suites/express/span-isolationScope/test.ts
@@ -0,0 +1,39 @@
+import { cleanupChildProcesses, createRunner } from '../../../utils/runner';
+
+afterAll(() => {
+  cleanupChildProcesses();
+});
+
+test('correctly applies isolation scope to span', done => {
+  createRunner(__dirname, 'server.ts')
+    .ignore('session', 'sessions')
+    .expect({
+      transaction: {
+        transaction: 'GET /test/isolationScope',
+        breadcrumbs: [
+          {
+            category: 'console',
+            level: 'log',
+            message: expect.stringMatching(/\{"port":(\d+)\}/),
+            timestamp: expect.any(Number),
+          },
+          {
+            category: 'console',
+            level: 'log',
+            message: 'This is a test log.',
+            timestamp: expect.any(Number),
+          },
+          {
+            message: 'manual breadcrumb',
+            timestamp: expect.any(Number),
+          },
+        ],
+        tags: {
+          global: 'tag',
+          'isolation-scope': 'tag',
+        },
+      },
+    })
+    .start(done)
+    .makeRequest('get', '/test/isolationScope');
+});