diff --git a/CHANGELOG.md b/CHANGELOG.md
index e7357327..86379da8 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -8,6 +8,7 @@
 
 ### Bugs fixed
 
+* [#565](https://github.com/clojure-emacs/clojure-mode/issues/565): Fix extra spaces being inserted after quote in paredit-mode.
 * [#544](https://github.com/clojure-emacs/clojure-mode/issues/544): Fix docstring detection when string contains backslash.
 * [#547](https://github.com/clojure-emacs/clojure-mode/issues/547): Fix font-lock regex for character literals for uppercase chars and other symbols.
 * [#556](https://github.com/clojure-emacs/clojure-mode/issues/556): Fix renaming of ns aliases containing regex characters.
diff --git a/Cask b/Cask
index d6771c81..abcd75fd 100644
--- a/Cask
+++ b/Cask
@@ -5,4 +5,5 @@
 
 (development
  (depends-on "s")
- (depends-on "buttercup"))
+ (depends-on "buttercup")
+ (depends-on "paredit"))
diff --git a/clojure-mode.el b/clojure-mode.el
index 4abc7015..994c8bc6 100644
--- a/clojure-mode.el
+++ b/clojure-mode.el
@@ -456,21 +456,13 @@ The command will prompt you to select one of the available sections."
   "Prevent paredit from inserting useless spaces.
 See `paredit-space-for-delimiter-predicates' for the meaning of
 ENDP and DELIM."
-  (or endp
-      (not (memq delim '(?\" ?{ ?\( )))
-      (not (or (derived-mode-p 'clojure-mode)
-               (derived-mode-p 'cider-repl-mode)))
-      (save-excursion
-        (backward-char)
-        (cond ((eq (char-after) ?#)
-               (and (not (bobp))
-                    (or (char-equal ?w (char-syntax (char-before)))
-                        (char-equal ?_ (char-syntax (char-before))))))
-              ((and (eq delim ?\()
-                    (eq (char-after) ??)
-                    (eq (char-before) ?#))
-               nil)
-              (t)))))
+  (and (not endp)
+       ;; don't insert after opening quotes, auto-gensym syntax, or reader tags
+       (not (looking-back
+             (if (member delim clojure-omit-space-between-tag-and-delimiters)
+                 "\\_<\\(?:'+\\|#.*\\)"
+               "\\_<\\(?:'+\\|#\\)")
+             (point-at-bol)))))
 
 (defconst clojure--collection-tag-regexp "#\\(::[a-zA-Z0-9._-]*\\|:?\\([a-zA-Z0-9._-]+/\\)?[a-zA-Z0-9._-]+\\)"
   "Collection reader macro tag regexp.
@@ -479,29 +471,8 @@ collection literal (e.g. '[]' or '{}'), as reader macro tags.
 This includes #fully.qualified/my-ns[:kw val] and #::my-ns{:kw
 val} as of Clojure 1.9.")
 
-(defun clojure-no-space-after-tag (endp delimiter)
-  "Prevent inserting a space after a reader-literal tag.
-
-When a reader-literal tag is followed be an opening delimiter
-listed in `clojure-omit-space-between-tag-and-delimiters', this
-function returns t.
-
-This allows you to write things like #db/id[:db.part/user]
-and #::my-ns{:some \"map\"} without inserting a space between
-the tag and the opening bracket.
-
-See `paredit-space-for-delimiter-predicates' for the meaning of
-ENDP and DELIMITER."
-  (if endp
-      t
-    (or (not (member delimiter clojure-omit-space-between-tag-and-delimiters))
-        (save-excursion
-          (let ((orig-point (point)))
-            (not (and (re-search-backward
-                       clojure--collection-tag-regexp
-                       (line-beginning-position)
-                       t)
-                      (= orig-point (match-end 0)))))))))
+(make-obsolete-variable 'clojure--collection-tag-regexp nil "5.12.0")
+(make-obsolete #'clojure-no-space-after-tag #'clojure-space-for-delimiter-p "5.12.0")
 
 (declare-function paredit-open-curly "ext:paredit" t t)
 (declare-function paredit-close-curly "ext:paredit" t t)
@@ -525,10 +496,9 @@ replacement for `cljr-expand-let`."
     (let ((keymap (or keymap clojure-mode-map)))
       (define-key keymap "{" #'paredit-open-curly)
       (define-key keymap "}" #'paredit-close-curly))
+    (make-local-variable 'paredit-space-for-delimiter-predicates)
     (add-to-list 'paredit-space-for-delimiter-predicates
                  #'clojure-space-for-delimiter-p)
-    (add-to-list 'paredit-space-for-delimiter-predicates
-                 #'clojure-no-space-after-tag)
     (advice-add 'paredit-convolute-sexp :after #'clojure--replace-let-bindings-and-indent)))
 
 (defun clojure-mode-variables ()
diff --git a/test/clojure-mode-external-interaction-test.el b/test/clojure-mode-external-interaction-test.el
new file mode 100644
index 00000000..8451abe1
--- /dev/null
+++ b/test/clojure-mode-external-interaction-test.el
@@ -0,0 +1,134 @@
+;;; clojure-mode-external-interaction-test.el --- Clojure Mode interactions with external packages test suite  -*- lexical-binding: t; -*-
+
+;; Copyright (C) 2014-2020 Bozhidar Batsov <bozhidar@batsov.com>
+
+;; This file is not part of GNU Emacs.
+
+;; This program is free software; you can redistribute it and/or modify
+;; it under the terms of the GNU General Public License as published by
+;; the Free Software Foundation, either version 3 of the License, or
+;; (at your option) any later version.
+
+;; This program is distributed in the hope that it will be useful,
+;; but WITHOUT ANY WARRANTY; without even the implied warranty of
+;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
+;; GNU General Public License for more details.
+
+;; You should have received a copy of the GNU General Public License
+;; along with this program.  If not, see <http://www.gnu.org/licenses/>.
+
+;;; Code:
+
+(require 'clojure-mode)
+(require 'buttercup)
+(require 'paredit)
+
+(describe "Interactions with Paredit:"
+  ;; reuse existing when-refactoring-it macro
+  (describe "it should insert a space"
+    (when-refactoring-it "before lists"
+      "foo"
+      "foo ()"
+      (paredit-mode)
+      (paredit-open-round))
+    (when-refactoring-it "before vectors"
+      "foo"
+      "foo []"
+      (paredit-mode)
+      (paredit-open-square))
+    (when-refactoring-it "before maps"
+      "foo"
+      "foo {}"
+      (paredit-mode)
+      (paredit-open-curly))
+    (when-refactoring-it "before strings"
+      "foo"
+      "foo \"\""
+      (paredit-mode)
+      (paredit-doublequote))
+    (when-refactoring-it "after gensym"
+      "foo#"
+      "foo# ()"
+      (paredit-mode)
+      (paredit-open-round))
+    (when-refactoring-it "after symbols ending with '"
+      "foo'"
+      "foo' ()"
+      (paredit-mode)
+      (paredit-open-round)))
+  (describe "it should not insert a space"
+    (when-refactoring-it "for anonymous fn syntax"
+      "foo #"
+      "foo #()"
+      (paredit-mode)
+      (paredit-open-round))
+    (when-refactoring-it "for hash sets"
+      "foo #"
+      "foo #{}"
+      (paredit-mode)
+      (paredit-open-curly))
+    (when-refactoring-it "for regexes"
+      "foo #"
+      "foo #\"\""
+      (paredit-mode)
+      (paredit-doublequote))
+    (when-refactoring-it "for quoted collections"
+      "foo '"
+      "foo '()"
+      (paredit-mode)
+      (paredit-open-round))
+    (when-refactoring-it "for reader conditionals"
+      "foo #?"
+      "foo #?()"
+      (paredit-mode)
+      (paredit-open-round)))
+  (describe "reader tags"
+    (when-refactoring-it "should insert a space before strings"
+      "#uuid"
+      "#uuid \"\""
+      (paredit-mode)
+      (paredit-doublequote))
+    (when-refactoring-it "should not insert a space before namespaced maps"
+      "#::my-ns"
+      "#::my-ns{}"
+      (paredit-mode)
+      (paredit-open-curly))
+    (when-refactoring-it "should not insert a space before namespaced maps 2"
+      "#::"
+      "#::{}"
+      (paredit-mode)
+      (paredit-open-curly))
+    (when-refactoring-it "should not insert a space before namespaced maps 3"
+      "#:fully.qualified.ns123.-$#.%*+!"
+      "#:fully.qualified.ns123.-$#.%*+!{}"
+      (paredit-mode)
+      (paredit-open-curly))
+    (when-refactoring-it "should not insert a space before tagged vectors"
+      "#tag123.-$#.%*+!"
+      "#tag123.-$#.%*+![]"
+      (paredit-mode)
+      (paredit-open-square))))
+
+
+(describe "Interactions with delete-trailing-whitespace"
+  (when-refactoring-it "should not delete trailing commas"
+    "(def foo
+    \\\"foo\\\": 1,
+    \\\"bar\\\": 2}
+
+(-> m
+  (assoc ,,,
+    :foo 123))"
+    "(def foo
+    \\\"foo\\\": 1,
+    \\\"bar\\\": 2}
+
+(-> m
+  (assoc ,,,
+    :foo 123))"
+    (delete-trailing-whitespace)))
+
+(provide 'clojure-mode-external-interaction-test)
+
+
+;;; clojure-mode-external-interaction-test.el ends here
diff --git a/test/clojure-mode-syntax-test.el b/test/clojure-mode-syntax-test.el
index af00c1a7..f3699f67 100644
--- a/test/clojure-mode-syntax-test.el
+++ b/test/clojure-mode-syntax-test.el
@@ -75,15 +75,6 @@
         (backward-prefix-chars)
         (expect (bobp))))))
 
-(describe "clojure-no-space-after-tag"
-  (it "should allow allow collection tags"
-    (dolist (tag '("#::ns" "#:ns" "#ns" "#:f.q/ns" "#f.q/ns" "#::"))
-      (with-clojure-buffer tag
-        (expect (clojure-no-space-after-tag nil ?{) :to-be nil)))
-    (dolist (tag '("#$:" "#/f" "#:/f" "#::f.q/ns" "::ns" "::" "#f:ns"))
-      (with-clojure-buffer tag
-        (expect (clojure-no-space-after-tag nil ?{))))))
-
 (describe "fill-paragraph"
 
   (it "should work within comments"