diff --git a/src/material/radio/radio.spec.ts b/src/material/radio/radio.spec.ts
index 5aec8aef5b85..1e32fc0f1cad 100644
--- a/src/material/radio/radio.spec.ts
+++ b/src/material/radio/radio.spec.ts
@@ -471,6 +471,19 @@ describe('MDC-based MatRadio', () => {
         }),
       ).toEqual(['-1', '-1', '0']);
     });
+
+    it('should clear the selected radio button but preserve the value on destroy', () => {
+      radioLabelElements[0].click();
+      fixture.detectChanges();
+      expect(groupInstance.selected).toBe(radioInstances[0]);
+      expect(groupInstance.value).toBe('fire');
+
+      fixture.componentInstance.isFirstShown = false;
+      fixture.detectChanges();
+
+      expect(groupInstance.selected).toBe(null);
+      expect(groupInstance.value).toBe('fire');
+    });
   });
 
   describe('group with ngModel', () => {
@@ -995,7 +1008,7 @@ describe('MatRadioDefaultOverrides', () => {
                   [value]="groupValue"
                   name="test-name">
     <mat-radio-button value="fire" [disableRipple]="disableRipple" [disabled]="isFirstDisabled"
-                     [color]="color">
+                     [color]="color" *ngIf="isFirstShown">
       Charmander
     </mat-radio-button>
     <mat-radio-button value="water" [disableRipple]="disableRipple" [color]="color">
@@ -1009,12 +1022,13 @@ describe('MatRadioDefaultOverrides', () => {
 })
 class RadiosInsideRadioGroup {
   labelPos: 'before' | 'after';
-  isFirstDisabled: boolean = false;
-  isGroupDisabled: boolean = false;
-  isGroupRequired: boolean = false;
+  isFirstDisabled = false;
+  isGroupDisabled = false;
+  isGroupRequired = false;
   groupValue: string | null = null;
-  disableRipple: boolean = false;
+  disableRipple = false;
   color: string | null;
+  isFirstShown = true;
 }
 
 @Component({
diff --git a/src/material/radio/radio.ts b/src/material/radio/radio.ts
index 367bfbebbb86..72aa7cb0e666 100644
--- a/src/material/radio/radio.ts
+++ b/src/material/radio/radio.ts
@@ -42,6 +42,7 @@ import {BooleanInput, coerceBooleanProperty, coerceNumberProperty} from '@angula
 import {UniqueSelectionDispatcher} from '@angular/cdk/collections';
 import {ANIMATION_MODULE_TYPE} from '@angular/platform-browser/animations';
 import {ControlValueAccessor, NG_VALUE_ACCESSOR} from '@angular/forms';
+import {Subscription} from 'rxjs';
 
 // Increasing integer for generating unique ids for radio components.
 let nextUniqueId = 0;
@@ -100,7 +101,7 @@ export function MAT_RADIO_DEFAULT_OPTIONS_FACTORY(): MatRadioDefaultOptions {
  */
 @Directive()
 export abstract class _MatRadioGroupBase<T extends _MatRadioButtonBase>
-  implements AfterContentInit, ControlValueAccessor
+  implements AfterContentInit, OnDestroy, ControlValueAccessor
 {
   /** Selected value for the radio group. */
   private _value: any = null;
@@ -123,6 +124,9 @@ export abstract class _MatRadioGroupBase<T extends _MatRadioButtonBase>
   /** Whether the radio group is required. */
   private _required: boolean = false;
 
+  /** Subscription to changes in amount of radio buttons. */
+  private _buttonChanges: Subscription;
+
   /** The method to be called in order to update ngModel */
   _controlValueAccessorChangeFn: (value: any) => void = () => {};
 
@@ -236,6 +240,20 @@ export abstract class _MatRadioGroupBase<T extends _MatRadioButtonBase>
     // possibly be set by NgModel on MatRadioGroup, and it is possible that the OnInit of the
     // NgModel occurs *after* the OnInit of the MatRadioGroup.
     this._isInitialized = true;
+
+    // Clear the `selected` button when it's destroyed since the tabindex of the rest of the
+    // buttons depends on it. Note that we don't clear the `value`, because the radio button
+    // may be swapped out with a similar one and there are some internal apps that depend on
+    // that behavior.
+    this._buttonChanges = this._radios.changes.subscribe(() => {
+      if (this.selected && !this._radios.find(radio => radio === this.selected)) {
+        this._selected = null;
+      }
+    });
+  }
+
+  ngOnDestroy() {
+    this._buttonChanges?.unsubscribe();
   }
 
   /**
diff --git a/tools/public_api_guard/material/radio.md b/tools/public_api_guard/material/radio.md
index fc19d0686502..5eade5af5fb8 100644
--- a/tools/public_api_guard/material/radio.md
+++ b/tools/public_api_guard/material/radio.md
@@ -124,7 +124,7 @@ export class MatRadioGroup extends _MatRadioGroupBase<MatRadioButton> {
 }
 
 // @public
-export abstract class _MatRadioGroupBase<T extends _MatRadioButtonBase> implements AfterContentInit, ControlValueAccessor {
+export abstract class _MatRadioGroupBase<T extends _MatRadioButtonBase> implements AfterContentInit, OnDestroy, ControlValueAccessor {
     constructor(_changeDetector: ChangeDetectorRef);
     readonly change: EventEmitter<MatRadioChange>;
     // (undocumented)
@@ -141,6 +141,8 @@ export abstract class _MatRadioGroupBase<T extends _MatRadioButtonBase> implemen
     get name(): string;
     set name(value: string);
     ngAfterContentInit(): void;
+    // (undocumented)
+    ngOnDestroy(): void;
     onTouched: () => any;
     abstract _radios: QueryList<T>;
     registerOnChange(fn: (value: any) => void): void;