diff --git a/src/material/progress-spinner/BUILD.bazel b/src/material/progress-spinner/BUILD.bazel
index c1535578c6e0..2de0e6ce53c4 100644
--- a/src/material/progress-spinner/BUILD.bazel
+++ b/src/material/progress-spinner/BUILD.bazel
@@ -22,6 +22,7 @@ ng_module(
     deps = [
         "//src/cdk/coercion",
         "//src/cdk/platform",
+        "//src/cdk/scrolling",
         "//src/material/core",
         "@npm//@angular/animations",
         "@npm//@angular/common",
diff --git a/src/material/progress-spinner/progress-spinner.html b/src/material/progress-spinner/progress-spinner.html
index 29c093050abd..9156f5d44a4c 100644
--- a/src/material/progress-spinner/progress-spinner.html
+++ b/src/material/progress-spinner/progress-spinner.html
@@ -14,7 +14,8 @@
   preserveAspectRatio="xMidYMid meet"
   focusable="false"
   [ngSwitch]="mode === 'indeterminate'"
-  aria-hidden="true">
+  aria-hidden="true"
+  #svg>
 
   <!--
     Technically we can reuse the same `circle` element, however Safari has an issue that breaks
@@ -31,7 +32,8 @@
     [style.animation-name]="'mat-progress-spinner-stroke-rotate-' + _spinnerAnimationLabel"
     [style.stroke-dashoffset.px]="_getStrokeDashOffset()"
     [style.stroke-dasharray.px]="_getStrokeCircumference()"
-    [style.stroke-width.%]="_getCircleStrokeWidth()"></circle>
+    [style.stroke-width.%]="_getCircleStrokeWidth()"
+    [style.transform-origin]="_getCircleTransformOrigin(svg)"></circle>
 
   <circle
     *ngSwitchCase="false"
@@ -40,5 +42,6 @@
     [attr.r]="_getCircleRadius()"
     [style.stroke-dashoffset.px]="_getStrokeDashOffset()"
     [style.stroke-dasharray.px]="_getStrokeCircumference()"
-    [style.stroke-width.%]="_getCircleStrokeWidth()"></circle>
+    [style.stroke-width.%]="_getCircleStrokeWidth()"
+    [style.transform-origin]="_getCircleTransformOrigin(svg)"></circle>
 </svg>
diff --git a/src/material/progress-spinner/progress-spinner.scss b/src/material/progress-spinner/progress-spinner.scss
index fd7b1e45b111..67b864798104 100644
--- a/src/material/progress-spinner/progress-spinner.scss
+++ b/src/material/progress-spinner/progress-spinner.scss
@@ -26,7 +26,6 @@ $_default-circumference: variables.$pi * $_default-radius * 2;
   circle {
     @include private.private-animation-noop();
     fill: transparent;
-    transform-origin: center;
     transition: stroke-dashoffset 225ms linear;
 
     @include a11y.high-contrast(active, off) {
diff --git a/src/material/progress-spinner/progress-spinner.ts b/src/material/progress-spinner/progress-spinner.ts
index 568887129ba7..38627412e579 100644
--- a/src/material/progress-spinner/progress-spinner.ts
+++ b/src/material/progress-spinner/progress-spinner.ts
@@ -8,6 +8,7 @@
 
 import {coerceNumberProperty, NumberInput} from '@angular/cdk/coercion';
 import {Platform, _getShadowRoot} from '@angular/cdk/platform';
+import {ViewportRuler} from '@angular/cdk/scrolling';
 import {DOCUMENT} from '@angular/common';
 import {
   ChangeDetectionStrategy,
@@ -19,9 +20,13 @@ import {
   Optional,
   ViewEncapsulation,
   OnInit,
+  ChangeDetectorRef,
+  OnDestroy,
+  NgZone,
 } from '@angular/core';
 import {CanColor, mixinColor} from '@angular/material/core';
 import {ANIMATION_MODULE_TYPE} from '@angular/platform-browser/animations';
+import {Subscription} from 'rxjs';
 
 /** Possible mode for a progress spinner. */
 export type ProgressSpinnerMode = 'determinate' | 'indeterminate';
@@ -126,10 +131,14 @@ const INDETERMINATE_ANIMATION_TEMPLATE = `
   changeDetection: ChangeDetectionStrategy.OnPush,
   encapsulation: ViewEncapsulation.None,
 })
-export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnInit, CanColor {
+export class MatProgressSpinner
+  extends _MatProgressSpinnerBase
+  implements OnInit, OnDestroy, CanColor
+{
   private _diameter = BASE_SIZE;
   private _value = 0;
   private _strokeWidth: number;
+  private _resizeSubscription = Subscription.EMPTY;
 
   /**
    * Element to which we should add the generated style tags for the indeterminate animation.
@@ -190,15 +199,19 @@ export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnIni
 
   constructor(
     elementRef: ElementRef<HTMLElement>,
-    /**
-     * @deprecated `_platform` parameter no longer being used.
-     * @breaking-change 14.0.0
-     */
     _platform: Platform,
     @Optional() @Inject(DOCUMENT) private _document: any,
     @Optional() @Inject(ANIMATION_MODULE_TYPE) animationMode: string,
     @Inject(MAT_PROGRESS_SPINNER_DEFAULT_OPTIONS)
     defaults?: MatProgressSpinnerDefaultOptions,
+    /**
+     * @deprecated `changeDetectorRef`, `viewportRuler` and `ngZone`
+     * parameters to become required.
+     * @breaking-change 14.0.0
+     */
+    changeDetectorRef?: ChangeDetectorRef,
+    viewportRuler?: ViewportRuler,
+    ngZone?: NgZone,
   ) {
     super(elementRef);
 
@@ -223,6 +236,22 @@ export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnIni
         this.strokeWidth = defaults.strokeWidth;
       }
     }
+
+    // Safari has an issue where the circle isn't positioned correctly when the page has a
+    // different zoom level from the default. This handler triggers a recalculation of the
+    // `transform-origin` when the page zoom level changes.
+    // See `_getCircleTransformOrigin` for more info.
+    // @breaking-change 14.0.0 Remove null checks for `_changeDetectorRef`,
+    // `viewportRuler` and `ngZone`.
+    if (_platform.isBrowser && _platform.SAFARI && viewportRuler && changeDetectorRef && ngZone) {
+      this._resizeSubscription = viewportRuler.change(150).subscribe(() => {
+        // When the window is resize while the spinner is in `indeterminate` mode, we
+        // have to mark for check so the transform origin of the circle can be recomputed.
+        if (this.mode === 'indeterminate') {
+          ngZone.run(() => changeDetectorRef.markForCheck());
+        }
+      });
+    }
   }
 
   ngOnInit() {
@@ -236,6 +265,10 @@ export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnIni
     element.classList.add('mat-progress-spinner-indeterminate-animation');
   }
 
+  ngOnDestroy() {
+    this._resizeSubscription.unsubscribe();
+  }
+
   /** The radius of the spinner, adjusted for stroke width. */
   _getCircleRadius() {
     return (this.diameter - BASE_STROKE_WIDTH) / 2;
@@ -266,6 +299,16 @@ export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnIni
     return (this.strokeWidth / this.diameter) * 100;
   }
 
+  /** Gets the `transform-origin` for the inner circle element. */
+  _getCircleTransformOrigin(svg: HTMLElement): string {
+    // Safari has an issue where the `transform-origin` doesn't work as expected when the page
+    // has a different zoom level from the default. The problem appears to be that a zoom
+    // is applied on the `svg` node itself. We can work around it by calculating the origin
+    // based on the zoom level. On all other browsers the `currentScale` appears to always be 1.
+    const scale = ((svg as unknown as SVGSVGElement).currentScale ?? 1) * 50;
+    return `${scale}% ${scale}%`;
+  }
+
   /** Dynamically generates a style tag containing the correct animation for this diameter. */
   private _attachStyleNode(): void {
     const styleRoot = this._styleRoot;
@@ -338,8 +381,25 @@ export class MatSpinner extends MatProgressSpinner {
     @Optional() @Inject(ANIMATION_MODULE_TYPE) animationMode: string,
     @Inject(MAT_PROGRESS_SPINNER_DEFAULT_OPTIONS)
     defaults?: MatProgressSpinnerDefaultOptions,
+    /**
+     * @deprecated `changeDetectorRef`, `viewportRuler` and `ngZone`
+     * parameters to become required.
+     * @breaking-change 14.0.0
+     */
+    changeDetectorRef?: ChangeDetectorRef,
+    viewportRuler?: ViewportRuler,
+    ngZone?: NgZone,
   ) {
-    super(elementRef, platform, document, animationMode, defaults);
+    super(
+      elementRef,
+      platform,
+      document,
+      animationMode,
+      defaults,
+      changeDetectorRef,
+      viewportRuler,
+      ngZone,
+    );
     this.mode = 'indeterminate';
   }
 }
diff --git a/tools/public_api_guard/material/progress-spinner.md b/tools/public_api_guard/material/progress-spinner.md
index 3af5b8ca941b..91a5628c446e 100644
--- a/tools/public_api_guard/material/progress-spinner.md
+++ b/tools/public_api_guard/material/progress-spinner.md
@@ -6,15 +6,19 @@
 
 import { _AbstractConstructor } from '@angular/material/core';
 import { CanColor } from '@angular/material/core';
+import { ChangeDetectorRef } from '@angular/core';
 import { _Constructor } from '@angular/material/core';
 import { ElementRef } from '@angular/core';
 import * as i0 from '@angular/core';
 import * as i2 from '@angular/material/core';
 import * as i3 from '@angular/common';
 import { InjectionToken } from '@angular/core';
+import { NgZone } from '@angular/core';
 import { NumberInput } from '@angular/cdk/coercion';
+import { OnDestroy } from '@angular/core';
 import { OnInit } from '@angular/core';
 import { Platform } from '@angular/cdk/platform';
+import { ViewportRuler } from '@angular/cdk/scrolling';
 
 // @public
 export const MAT_PROGRESS_SPINNER_DEFAULT_OPTIONS: InjectionToken<MatProgressSpinnerDefaultOptions>;
@@ -23,18 +27,21 @@ export const MAT_PROGRESS_SPINNER_DEFAULT_OPTIONS: InjectionToken<MatProgressSpi
 export function MAT_PROGRESS_SPINNER_DEFAULT_OPTIONS_FACTORY(): MatProgressSpinnerDefaultOptions;
 
 // @public
-export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnInit, CanColor {
-    constructor(elementRef: ElementRef<HTMLElement>,
-    _platform: Platform, _document: any, animationMode: string, defaults?: MatProgressSpinnerDefaultOptions);
+export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnInit, OnDestroy, CanColor {
+    constructor(elementRef: ElementRef<HTMLElement>, _platform: Platform, _document: any, animationMode: string, defaults?: MatProgressSpinnerDefaultOptions,
+    changeDetectorRef?: ChangeDetectorRef, viewportRuler?: ViewportRuler, ngZone?: NgZone);
     get diameter(): number;
     set diameter(size: NumberInput);
     _getCircleRadius(): number;
     _getCircleStrokeWidth(): number;
+    _getCircleTransformOrigin(svg: HTMLElement): string;
     _getStrokeCircumference(): number;
     _getStrokeDashOffset(): number | null;
     _getViewBox(): string;
     mode: ProgressSpinnerMode;
     // (undocumented)
+    ngOnDestroy(): void;
+    // (undocumented)
     ngOnInit(): void;
     _noopAnimations: boolean;
     _spinnerAnimationLabel: string;
@@ -45,7 +52,7 @@ export class MatProgressSpinner extends _MatProgressSpinnerBase implements OnIni
     // (undocumented)
     static ɵcmp: i0.ɵɵComponentDeclaration<MatProgressSpinner, "mat-progress-spinner", ["matProgressSpinner"], { "color": "color"; "diameter": "diameter"; "strokeWidth": "strokeWidth"; "mode": "mode"; "value": "value"; }, {}, never, never>;
     // (undocumented)
-    static ɵfac: i0.ɵɵFactoryDeclaration<MatProgressSpinner, [null, null, { optional: true; }, { optional: true; }, null]>;
+    static ɵfac: i0.ɵɵFactoryDeclaration<MatProgressSpinner, [null, null, { optional: true; }, { optional: true; }, null, null, null, null]>;
 }
 
 // @public
@@ -67,11 +74,12 @@ export class MatProgressSpinnerModule {
 
 // @public
 export class MatSpinner extends MatProgressSpinner {
-    constructor(elementRef: ElementRef<HTMLElement>, platform: Platform, document: any, animationMode: string, defaults?: MatProgressSpinnerDefaultOptions);
+    constructor(elementRef: ElementRef<HTMLElement>, platform: Platform, document: any, animationMode: string, defaults?: MatProgressSpinnerDefaultOptions,
+    changeDetectorRef?: ChangeDetectorRef, viewportRuler?: ViewportRuler, ngZone?: NgZone);
     // (undocumented)
     static ɵcmp: i0.ɵɵComponentDeclaration<MatSpinner, "mat-spinner", never, { "color": "color"; }, {}, never, never>;
     // (undocumented)
-    static ɵfac: i0.ɵɵFactoryDeclaration<MatSpinner, [null, null, { optional: true; }, { optional: true; }, null]>;
+    static ɵfac: i0.ɵɵFactoryDeclaration<MatSpinner, [null, null, { optional: true; }, { optional: true; }, null, null, null, null]>;
 }
 
 // @public