diff --git a/src/material/autocomplete/autocomplete-trigger.ts b/src/material/autocomplete/autocomplete-trigger.ts
index f08faaaa33e8..d421d5acf5d6 100644
--- a/src/material/autocomplete/autocomplete-trigger.ts
+++ b/src/material/autocomplete/autocomplete-trigger.ts
@@ -360,9 +360,11 @@ export class MatAutocompleteTrigger implements ControlValueAccessor, AfterViewIn
               (this._isInsideShadowRoot && event.composedPath ? event.composedPath()[0] :
                                                                 event.target) as HTMLElement;
           const formField = this._formField ? this._formField._elementRef.nativeElement : null;
+          const customOrigin = this.connectedTo ? this.connectedTo.elementRef.nativeElement : null;
 
           return this._overlayAttached && clickTarget !== this._element.nativeElement &&
               (!formField || !formField.contains(clickTarget)) &&
+              (!customOrigin || !customOrigin.contains(clickTarget)) &&
               (!!this._overlayRef && !this._overlayRef.overlayElement.contains(clickTarget));
         }));
   }
@@ -722,7 +724,7 @@ export class MatAutocompleteTrigger implements ControlValueAccessor, AfterViewIn
     positionStrategy.withPositions(positions);
   }
 
-  private _getConnectedElement(): ElementRef {
+  private _getConnectedElement(): ElementRef<HTMLElement> {
     if (this.connectedTo) {
       return this.connectedTo.elementRef;
     }
diff --git a/src/material/autocomplete/autocomplete.spec.ts b/src/material/autocomplete/autocomplete.spec.ts
index c13393f7d6e0..560959316d3c 100644
--- a/src/material/autocomplete/autocomplete.spec.ts
+++ b/src/material/autocomplete/autocomplete.spec.ts
@@ -2593,6 +2593,25 @@ describe('MatAutocomplete', () => {
 
     expect(formControl.value).toBe('Cal', 'Expected new value to be propagated to model');
   }));
+
+  it('should not close when clicking inside alternate origin', () => {
+    const fixture = createComponent(AutocompleteWithDifferentOrigin);
+    fixture.detectChanges();
+    fixture.componentInstance.connectedTo = fixture.componentInstance.alternateOrigin;
+    fixture.detectChanges();
+    fixture.componentInstance.trigger.openPanel();
+    fixture.detectChanges();
+    zone.simulateZoneExit();
+
+    expect(fixture.componentInstance.trigger.panelOpen).toBe(true);
+
+    const origin = fixture.nativeElement.querySelector('.origin');
+    origin.click();
+    fixture.detectChanges();
+
+    expect(fixture.componentInstance.trigger.panelOpen).toBe(true);
+  });
+
 });
 
 const SIMPLE_AUTOCOMPLETE_TEMPLATE = `