diff --git a/src/material-experimental/mdc-autocomplete/autocomplete-trigger.ts b/src/material-experimental/mdc-autocomplete/autocomplete-trigger.ts
index 4c2196b28c5b..4a69e5c347ae 100644
--- a/src/material-experimental/mdc-autocomplete/autocomplete-trigger.ts
+++ b/src/material-experimental/mdc-autocomplete/autocomplete-trigger.ts
@@ -38,7 +38,7 @@ export const MAT_AUTOCOMPLETE_VALUE_ACCESSOR: any = {
     // Note: we use `focusin`, as opposed to `focus`, in order to open the panel
     // a little earlier. This avoids issues where IE delays the focusing of the input.
     '(focusin)': '_handleFocus()',
-    '(blur)': '_onTouched()',
+    '(blur)': '_handleBlur($event)',
     '(input)': '_handleInput($event)',
     '(keydown)': '_handleKeydown($event)',
     '(click)': '_handleClick()',
diff --git a/src/material-experimental/mdc-autocomplete/autocomplete.spec.ts b/src/material-experimental/mdc-autocomplete/autocomplete.spec.ts
index fdd8d06cd0a4..ad1bfecfe28f 100644
--- a/src/material-experimental/mdc-autocomplete/autocomplete.spec.ts
+++ b/src/material-experimental/mdc-autocomplete/autocomplete.spec.ts
@@ -917,8 +917,6 @@ describe('MDC-based MatAutocomplete', () => {
     });
 
     it('should mark the autocomplete control as touched on blur', () => {
-      fixture.componentInstance.trigger.openPanel();
-      fixture.detectChanges();
       expect(fixture.componentInstance.stateCtrl.touched)
         .withContext(`Expected control to start out untouched.`)
         .toBe(false);
@@ -931,6 +929,67 @@ describe('MDC-based MatAutocomplete', () => {
         .toBe(true);
     });
 
+    it('should mark the autocomplete control as touched when the panel is closed via the keyboard', fakeAsync(() => {
+      fixture.componentInstance.trigger.openPanel();
+      fixture.detectChanges();
+      zone.simulateZoneExit();
+
+      expect(fixture.componentInstance.stateCtrl.touched).toBe(
+        false,
+        `Expected control to start out untouched.`,
+      );
+
+      dispatchKeyboardEvent(input, 'keydown', TAB);
+      fixture.detectChanges();
+
+      expect(fixture.componentInstance.stateCtrl.touched).toBe(
+        true,
+        `Expected control to become touched on blur.`,
+      );
+    }));
+
+    it('should mark the autocomplete control as touched when the panel is closed by clicking away', fakeAsync(() => {
+      fixture.componentInstance.trigger.openPanel();
+      fixture.detectChanges();
+      zone.simulateZoneExit();
+
+      expect(fixture.componentInstance.stateCtrl.touched).toBe(
+        false,
+        `Expected control to start out untouched.`,
+      );
+
+      dispatchFakeEvent(document, 'click');
+      fixture.detectChanges();
+
+      expect(fixture.componentInstance.stateCtrl.touched).toBe(
+        true,
+        `Expected control to become touched on blur.`,
+      );
+    }));
+
+    it(
+      'should not mark the autocomplete control as touched when the panel is closed ' +
+        'programmatically',
+      fakeAsync(() => {
+        fixture.componentInstance.trigger.openPanel();
+        fixture.detectChanges();
+        zone.simulateZoneExit();
+
+        expect(fixture.componentInstance.stateCtrl.touched).toBe(
+          false,
+          `Expected control to start out untouched.`,
+        );
+
+        fixture.componentInstance.trigger.closePanel();
+        fixture.detectChanges();
+
+        expect(fixture.componentInstance.stateCtrl.touched).toBe(
+          false,
+          `Expected control to stay untouched.`,
+        );
+      }),
+    );
+
     it('should disable the input when used with a value accessor and without `matInput`', () => {
       fixture.destroy();
       TestBed.resetTestingModule();
diff --git a/src/material/autocomplete/autocomplete-trigger.ts b/src/material/autocomplete/autocomplete-trigger.ts
index e7685d53d5a7..e294362570ce 100644
--- a/src/material/autocomplete/autocomplete-trigger.ts
+++ b/src/material/autocomplete/autocomplete-trigger.ts
@@ -480,6 +480,12 @@ export abstract class _MatAutocompleteTriggerBase
     }
   }
 
+  _handleBlur(event: FocusEvent) {
+    if (!this.panelOpen || !event.isTrusted) {
+      this._onTouched();
+    }
+  }
+
   /**
    * In "auto" mode, the label will animate down as soon as focus is lost.
    * This causes the value to jump when selecting an option with the mouse.
@@ -600,6 +606,7 @@ export abstract class _MatAutocompleteTriggerBase
       this._element.nativeElement.focus();
     }
 
+    this._onTouched();
     this.closePanel();
   }
 
@@ -835,8 +842,8 @@ export abstract class _MatAutocompleteTriggerBase
     // Note: we use `focusin`, as opposed to `focus`, in order to open the panel
     // a little earlier. This avoids issues where IE delays the focusing of the input.
     '(focusin)': '_handleFocus()',
-    '(blur)': '_onTouched()',
     '(input)': '_handleInput($event)',
+    '(blur)': '_handleBlur($event)',
     '(keydown)': '_handleKeydown($event)',
     '(click)': '_handleClick()',
   },
diff --git a/src/material/autocomplete/autocomplete.spec.ts b/src/material/autocomplete/autocomplete.spec.ts
index 3e2fc09f30c7..27a1300e564d 100644
--- a/src/material/autocomplete/autocomplete.spec.ts
+++ b/src/material/autocomplete/autocomplete.spec.ts
@@ -912,8 +912,6 @@ describe('MatAutocomplete', () => {
     });
 
     it('should mark the autocomplete control as touched on blur', () => {
-      fixture.componentInstance.trigger.openPanel();
-      fixture.detectChanges();
       expect(fixture.componentInstance.stateCtrl.touched)
         .withContext(`Expected control to start out untouched.`)
         .toBe(false);
@@ -926,6 +924,63 @@ describe('MatAutocomplete', () => {
         .toBe(true);
     });
 
+    it('should mark the autocomplete control as touched when the panel is closed via the keyboard', fakeAsync(() => {
+      fixture.componentInstance.trigger.openPanel();
+      fixture.detectChanges();
+      zone.simulateZoneExit();
+
+      expect(fixture.componentInstance.stateCtrl.touched)
+        .withContext(`Expected control to start out untouched.`)
+        .toBe(false);
+
+      dispatchKeyboardEvent(input, 'keydown', TAB);
+      fixture.detectChanges();
+
+      expect(fixture.componentInstance.stateCtrl.touched)
+        .withContext(`Expected control to become touched on blur.`)
+        .toBe(true);
+    }));
+
+    it('should mark the autocomplete control as touched when the panel is closed by clicking away', fakeAsync(() => {
+      fixture.componentInstance.trigger.openPanel();
+      fixture.detectChanges();
+      zone.simulateZoneExit();
+
+      expect(fixture.componentInstance.stateCtrl.touched)
+        .withContext(`Expected control to start out untouched.`)
+        .toBe(false);
+
+      dispatchFakeEvent(document, 'click');
+      fixture.detectChanges();
+
+      expect(fixture.componentInstance.stateCtrl.touched)
+        .withContext(`Expected control to become touched on blur.`)
+        .toBe(true);
+    }));
+
+    it(
+      'should not mark the autocomplete control as touched when the panel is closed ' +
+        'programmatically',
+      fakeAsync(() => {
+        fixture.componentInstance.trigger.openPanel();
+        fixture.detectChanges();
+        zone.simulateZoneExit();
+
+        expect(fixture.componentInstance.stateCtrl.touched).toBe(
+          false,
+          `Expected control to start out untouched.`,
+        );
+
+        fixture.componentInstance.trigger.closePanel();
+        fixture.detectChanges();
+
+        expect(fixture.componentInstance.stateCtrl.touched).toBe(
+          false,
+          `Expected control to stay untouched.`,
+        );
+      }),
+    );
+
     it('should disable the input when used with a value accessor and without `matInput`', () => {
       overlayContainer.ngOnDestroy();
       fixture.destroy();
diff --git a/tools/public_api_guard/material/autocomplete.md b/tools/public_api_guard/material/autocomplete.md
index 8aaaa0b21737..59e8f96fe7b4 100644
--- a/tools/public_api_guard/material/autocomplete.md
+++ b/tools/public_api_guard/material/autocomplete.md
@@ -201,6 +201,8 @@ export abstract class _MatAutocompleteTriggerBase implements ControlValueAccesso
     closePanel(): void;
     connectedTo: _MatAutocompleteOriginBase;
     // (undocumented)
+    _handleBlur(event: FocusEvent): void;
+    // (undocumented)
     _handleClick(): void;
     // (undocumented)
     _handleFocus(): void;