diff --git a/Project.toml b/Project.toml
index 63aef5b8da..693a81e148 100644
--- a/Project.toml
+++ b/Project.toml
@@ -149,7 +149,7 @@ SpecialFunctions = "0.7, 0.8, 0.9, 0.10, 1.0, 2"
 StaticArrays = "0.10, 0.11, 0.12, 1.0"
 StochasticDelayDiffEq = "1.8.1"
 StochasticDiffEq = "6.72.1"
-SymbolicIndexingInterface = "0.3.37"
+SymbolicIndexingInterface = "0.3.39"
 SymbolicUtils = "3.25.1"
 Symbolics = "6.37"
 URIs = "1"
diff --git a/src/systems/parameter_buffer.jl b/src/systems/parameter_buffer.jl
index 36105c0de8..672fb58795 100644
--- a/src/systems/parameter_buffer.jl
+++ b/src/systems/parameter_buffer.jl
@@ -496,7 +496,119 @@ end
 function SymbolicIndexingInterface.remake_buffer(indp, oldbuf::MTKParameters, idxs, vals)
     _remake_buffer(indp, oldbuf, idxs, vals)
 end
+
+# For type-inference when using `SII.setp_oop`
+@generated function _remake_buffer(
+        indp, oldbuf::MTKParameters{T, I, D, C, N, H},
+        idxs::Union{Tuple{Vararg{ParameterIndex}}, AbstractArray{<:ParameterIndex{P}}},
+        vals::Union{AbstractArray, Tuple}; validate = true) where {T, I, D, C, N, H, P}
+
+    # fallback to non-generated method if values aren't type-stable
+    if vals <: AbstractArray && !isconcretetype(eltype(vals))
+        return quote
+            $__remake_buffer(indp, oldbuf, collect(idxs), vals; validate)
+        end
+    end
+
+    # given an index in idxs/vals and the current `eltype` of the buffer,
+    # return the promoted eltype of the buffer
+    function promote_valtype(i, valT)
+        # tuples have distinct types, arrays have a common eltype
+        valT′ = vals <: AbstractArray ? eltype(vals) : fieldtype(vals, i)
+        # if the buffer is a scalarized buffer but the variable is an array
+        # e.g. an array tunable, take the eltype
+        if valT′ <: AbstractArray && !(valT <: AbstractArray)
+            valT′ = eltype(valT′)
+        end
+        return promote_type(valT, valT′)
+    end
+
+    # types of the idxs
+    idxtypes = if idxs <: AbstractArray
+        # if both are arrays, there is only one possible type to check
+        if vals <: AbstractArray
+            (eltype(idxs),)
+        else
+            # if `vals` is a tuple, we repeat `eltype(idxs)` to check against
+            # every possible type of the buffer
+            ntuple(Returns(eltype(idxs)), Val(fieldcount(vals)))
+        end
+    else
+        # `idxs` is a tuple, so we check against all buffers
+        fieldtypes(idxs)
+    end
+    # promote types
+    tunablesT = eltype(T)
+    for (i, idxT) in enumerate(idxtypes)
+        idxT <: ParameterIndex{SciMLStructures.Tunable} || continue
+        tunablesT = promote_valtype(i, tunablesT)
+    end
+    initialsT = eltype(I)
+    for (i, idxT) in enumerate(idxtypes)
+        idxT <: ParameterIndex{SciMLStructures.Initials} || continue
+        initialsT = promote_valtype(i, initialsT)
+    end
+    discretesT = ntuple(Val(fieldcount(D))) do i
+        bufT = eltype(fieldtype(D, i))
+        for (j, idxT) in enumerate(idxtypes)
+            idxT <: ParameterIndex{SciMLStructures.Discrete, i} || continue
+            bufT = promote_valtype(i, bufT)
+        end
+        bufT
+    end
+    constantsT = ntuple(Val(fieldcount(C))) do i
+        bufT = eltype(fieldtype(C, i))
+        for (j, idxT) in enumerate(idxtypes)
+            idxT <: ParameterIndex{SciMLStructures.Constants, i} || continue
+            bufT = promote_valtype(i, bufT)
+        end
+        bufT
+    end
+    nonnumericT = ntuple(Val(fieldcount(N))) do i
+        bufT = eltype(fieldtype(N, i))
+        for (j, idxT) in enumerate(idxtypes)
+            idxT <: ParameterIndex{Nonnumeric, i} || continue
+            bufT = promote_valtype(i, bufT)
+        end
+        bufT
+    end
+
+    expr = quote
+        tunables = $similar(oldbuf.tunable, $tunablesT)
+        copyto!(tunables, oldbuf.tunable)
+        initials = $similar(oldbuf.initials, $initialsT)
+        copyto!(initials, oldbuf.initials)
+        discretes = $(Expr(:tuple,
+            (:($similar(oldbuf.discrete[$i], $(discretesT[i]))) for i in 1:length(discretesT))...))
+        $((:($copyto!(discretes[$i], oldbuf.discrete[$i])) for i in 1:length(discretesT))...)
+        constants = $(Expr(:tuple,
+            (:($similar(oldbuf.constant[$i], $(constantsT[i]))) for i in 1:length(constantsT))...))
+        $((:($copyto!(constants[$i], oldbuf.constant[$i])) for i in 1:length(constantsT))...)
+        nonnumerics = $(Expr(:tuple,
+            (:($similar(oldbuf.nonnumeric[$i], $(nonnumericT[i]))) for i in 1:length(nonnumericT))...))
+        $((:($copyto!(nonnumerics[$i], oldbuf.nonnumeric[$i])) for i in 1:length(nonnumericT))...)
+        newbuf = MTKParameters(
+            tunables, initials, discretes, constants, nonnumerics, copy.(oldbuf.caches))
+    end
+    if idxs <: AbstractArray
+        push!(expr.args, :(for (idx, val) in zip(idxs, vals)
+            $setindex!(newbuf, val, idx)
+        end))
+    else
+        for i in 1:fieldcount(idxs)
+            push!(expr.args, :($setindex!(newbuf, vals[$i], idxs[$i])))
+        end
+    end
+    push!(expr.args, :(return newbuf))
+
+    return expr
+end
+
 function _remake_buffer(indp, oldbuf::MTKParameters, idxs, vals; validate = true)
+    return __remake_buffer(indp, oldbuf, idxs, vals; validate)
+end
+
+function __remake_buffer(indp, oldbuf::MTKParameters, idxs, vals; validate = true)
     newbuf = @set oldbuf.tunable = similar(oldbuf.tunable, Any)
     @set! newbuf.initials = similar(oldbuf.initials, Any)
     @set! newbuf.discrete = Tuple(similar(buf, Any) for buf in newbuf.discrete)
diff --git a/test/mtkparameters.jl b/test/mtkparameters.jl
index f9d71f00bc..22201b1988 100644
--- a/test/mtkparameters.jl
+++ b/test/mtkparameters.jl
@@ -91,6 +91,27 @@ end
 @test getp(sys, f)(newps) isa Matrix{UInt}
 @test getp(sys, g)(newps) isa Vector{Float32}
 
+@testset "Type-stability of `remake_buffer`" begin
+    prob = ODEProblem(sys, [], (0.0, 1.0), ivs)
+
+    idxs = (a, c, d, e, f, g, h)
+    vals = (1.0, 2.0, 3, ones(3), ones(Int, 3, 3), ones(2), "a")
+
+    setter = setsym_oop(prob, idxs)
+    @test_nowarn @inferred setter(prob, vals)
+    @test_throws ErrorException @inferred setter(prob, collect(vals))
+
+    idxs = (a, c, e...)
+    vals = Float16[1.0, 2.0, 3.0, 4.0, 5.0]
+    setter = setsym_oop(prob, idxs)
+    @test_nowarn @inferred setter(prob, vals)
+
+    idxs = [a, e]
+    vals = (Float16(1.0), ForwardDiff.Dual{Nothing, Float16, 0}[1.0, 2.0, 3.0])
+    setter = setsym_oop(prob, idxs)
+    @test_nowarn @inferred setter(prob, vals)
+end
+
 ps = MTKParameters(sys, ivs)
 function loss(value, sys, ps)
     @test value isa ForwardDiff.Dual