diff --git a/azure-pipelines.yml b/azure-pipelines.yml
index e5b25fa..0334b7d 100644
--- a/azure-pipelines.yml
+++ b/azure-pipelines.yml
@@ -51,6 +51,11 @@ jobs:
           PYTHON_ARCH: "x64"
           NP_BUILD_DEP: "1.19.3"
           NIGHTLY_BUILD: "true"
+        py_3.10_64:
+          PYTHON_VERSION: "3.10"
+          PYTHON_ARCH: "x64"
+          NP_BUILD_DEP: "1.21.3"
+          NIGHTLY_BUILD: "true"
 
   - template: azure/posix.yml
     parameters:
@@ -104,7 +109,7 @@ jobs:
   - template: azure/posix.yml
     parameters:
       name: macOS
-      vmImage: macOS-10.14
+      vmImage: macOS-latest
       matrix:
         py_3.7_64:
           MB_PYTHON_VERSION: "3.7"
@@ -119,3 +124,8 @@ jobs:
           MB_PYTHON_VERSION: "3.9"
           NP_BUILD_DEP: "numpy==1.19.3"
           NIGHTLY_BUILD: "true"
+        py_3.10_64:
+          MB_PYTHON_VERSION: "3.10"
+          PLAT: universal2 # No numpy x86_64 wheels on MacOS anymore
+          NP_BUILD_DEP: "numpy==1.21.3"
+          NIGHTLY_BUILD: "true"
diff --git a/azure/posix.yml b/azure/posix.yml
index 52fcf28..fa85371 100644
--- a/azure/posix.yml
+++ b/azure/posix.yml
@@ -29,7 +29,6 @@ jobs:
         inputs:
           versionSpec: $(MB_PYTHON_VERSION)
         displayName: Set python version
-        condition: not(eq(variables['MB_PYTHON_VERSION'], '3.10'))
 
       - bash: |
           set -e
diff --git a/multibuild b/multibuild
index 7684e52..b89bb90 160000
--- a/multibuild
+++ b/multibuild
@@ -1 +1 @@
-Subproject commit 7684e52bcb023d511c4f17b638d497203f218a68
+Subproject commit b89bb903e94308be79abefa4f436bf123ebb1313